ID | 117727 |
著者 |
Sato, Mami
Tokushima University
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キーワード | virus
EB virus
autoimmunity
Sjögren’s syndrome
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資料タイプ |
学術雑誌論文
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抄録 | Sjögren’s syndrome (SS) is an autoimmune disease especially targeting exocrine glands, such as the salivary and lacrimal glands. A radical therapy for SS based on its etiology has not been established because of the complex pathogenesis of the disease. Several studies have demonstrated a relationship between virus infection and SS pathogenesis. In particular, infection with the Epstein-Barr (EB) virus among others is a potent factor associated with the onset or development of SS. Specifically, virus infection in the target organs of SS triggers or promotes autoreactive responses involving the process of autoantigen formation, antigen-presenting function, or T-cell response. Our review of recent research highlights the crucial roles of virus infection in the pathogenesis of SS and discusses the critical association between virus infection and the etiology of autoimmunity in SS.
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掲載誌名 |
Viruses
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ISSN | 19994915
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出版者 | MDPI
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巻 | 14
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号 | 7
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開始ページ | 1474
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発行日 | 2022-07-04
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権利情報 | This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
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EDB ID | |
出版社版DOI | |
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言語 |
eng
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著者版フラグ |
出版社版
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部局 |
ポストLEDフォトニクス研究所
医学系
歯学系
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