直近一年間の累計
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ID 117738
タイトル別表記
Treatment algorithm of ACTH deficiency
著者
Mitsui, Yukari Tokushima University
Iizuka, Yuto Tokushima University
Tanaka, Tomoaki Tokushima University
Masuda, Shiho Tokushima University
Ohnishi, Yukiyo Tokushima University
近藤, 剛史 Tokushima Red Cross Hospital KAKEN研究者をさがす
Kanezaki, Toshiko Tokushima Red Cross Hospital
Shintani, Yasumi Tokushima Red Cross Hospital
Yamaguchi, Yuki Tokushima Prefecture Naruto Hospital
Fujinaka, Yuichi Tokushima Prefecture Naruto Hospital
森本, 佳奈 Tokushima Prefectural Central Hospital
Shirakami, Atsuhisa Tokushima Prefectural Central Hospital
キーワード
central adrenal insufficiency
corticotropin-releasing hormone (CRH) test
dehydroepiandrosterone-sulfate (DHEA-S)
retrospective cohort study
treatment algorithm
資料タイプ
学術雑誌論文
抄録
Objective : To examine diagnostic performance of corticotropin-releasing hormone (CRH) test combined with baseline dehydroepiandrosterone sulfate (DHEA-S) in patients with a suspect of central adrenal insufficiency. Methods : Patients (n=215) requiring daily or intermittent hydrocortisone replacement, or no replacement were retrospectively checked with their peak cortisol after CRH test and baseline DHEA-S. Results : None of 106 patients with the peak cortisol ≥ 17.5 μg / dL after CRH test required replacement, and all 64 patients with the peak cortisol < 10.0 μg / dL required daily replacement. Among 8 patients with 10.0 μg / dL ≤ the peak cortisol < 17.5 μg / dL and baseline DHEA-S below the reference range, 6 patients required daily replacement and 1 patient was under intermittent replacement. Among 37 patients with 10.0 μg / dL ≤ the peak cortisol < 17.5 μg / dL and baseline DHEA-S within the reference range, 10 and 6 patients were under intermittent and daily replacement, respectively. Conclusions : No patients with the peak cortisol ≥ 17.5 μg / dL required hydrocortisone replacement, and all patients with the peak cortisol below 10.0 μg / dL required daily replacement. Careful clinical evaluation was required to determine requirement for replacement in patients with 10.0 μg / dL ≤ the peak cortisol < 17.5 μg / dL even in combination with baseline DHEA-S.
掲載誌名
The Journal of Medical Investigation
ISSN
13496867
13431420
cat書誌ID
AA11166929
出版者
Tokushima University Faculty of Medicine
69
3-4
開始ページ
287
終了ページ
293
並び順
287
発行日
2022-08
EDB ID
出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
出版社版
部局
医学系
病院
先端酵素学研究所