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ID 118316
タイトル別表記
液性因子および細胞性因子が成長期におけるリン誘導性の血管石灰化を抑制する
著者
亀井, 優輝 徳島大学大学院医科栄養学研究科(医科栄養学専攻) 徳島大学 教育研究者総覧
Okumura, Yosuke Tokushima University
Adachi, Yuichiro Tokushima University
Mori, Yuki Tokushima University
Sakai, Maiko Tokushima University
大西, 康太 Tokushima University
(山中)奥村, 仙示 Tokushima University|Doshisha Women’s College of Liberal Arts KAKEN研究者をさがす
キーワード
chronic kidney disease
hyperphosphatemia
fetuin-A
pyrophosphate
alkaline phosphatase
資料タイプ
学位論文
抄録
Hyperphosphatemia is an independent and non-classical risk factor of cardiovascular disease and mortality in patients with chronic kidney disease (CKD). Increased levels of extracellular inorganic phosphate (Pi) are known to directly induce vascular calcification, but the detailed underlying mechanism has not been clarified. Although serum Pi levels during the growth period are as high as those observed in hyperphosphatemia in adult CKD, vascular calcification does not usually occur during growth. Here, we have examined whether the defence system against Pi-induced vascular calcification can exist during the growth period using mice model. We found that calcification propensity of young serum (aged 3 weeks) was significantly lower than that of ‍adult serum (10 months), possibly due to high fetuin-A levels. In addition, when the aorta was cultured in high Pi medium in ‍vitro, obvious calcification was observed in the adult aorta but ‍not in the young aorta. Furthermore, culture in high Pi medium increased the mRNA level of tissue-nonspecific alkaline phosphatase (TNAP), which degrades pyrophosphate, only in the adult aorta. Collectively, our findings indicate that the aorta in growing mouse may be resistant to Pi-induced vascular calcification via a mechanism in which high serum fetuin-A levels and suppressed TNAP expression.
掲載誌名
Journal of Clinical Biochemistry and Nutrition
ISSN
18805086
09120009
cat書誌ID
AA10710201
出版者
Society for Free Radical Research Japan
73
3
開始ページ
198
終了ページ
204
発行日
2023-11-01
備考
内容要旨・審査要旨・論文本文の公開
本論文は,著者Yuki Kameiの学位論文として提出され,学位審査・授与の対象となっている。
権利情報
This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/).
出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
博士論文全文を含む
文科省報告番号
甲第3735号
学位記番号
甲栄第300号
学位授与年月日
2023-03-24
学位名
博士(栄養学)
学位授与機関
徳島大学
部局
医学系