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ID 118250
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血管内皮機能は心血管リスクを有する女性および非喫煙男性のeGFR slopeと関連している : 腎予後に対するFMDの予測能に関するパイロット研究
FMD and eGFR Slope in Males and Females
著者
桝田, 志保 徳島大学大学院医学研究科(医学専攻)
Mitsui, Yukari Tokushima University
乙田, 敏城 Tokushima University
キーワード
Sex difference
FMD
baPWV
eGFR slope
Cigarette smoking
資料タイプ
学位論文
抄録
Aims: It is known that there are sex differences in vascular endothelial function and the development of chronic kidney diseases; however, it remains unclear whether sex differences influence the association between vascular endothelial function and renal prognosis.
Methods: To clarify the relationship between vascular endothelial function and longitudinal eGFR changes in male and female patients with cardiovascular risk factors, we retrospectively evaluated 341 patients (176 males and 165 females) with cardiovascular risk factors in whom vascular function was assessed by flow-mediated dilation (FMD) and brachial ankle pulse wave velocity (baPWV) and in whom 24-month longitudinal eGFR values were recorded after the vascular function examinations. Associations of values of FMD and baPWV with values of eGFR slope were statistically analyzed.
Results: Simple regression analysis showed that the value of FMD was positively associated with eGFR slope in females (p=0.001) and non-smoking males (p=0.033) but not in smoking males. Multiple regression analysis showed that the value of FMD remains a positive contributor for eGFR slope in females (p=0.001) and nonsmoking males (p=0.045) but not in smoking males. In contrast, values of baPWV had no significant association with eGFR slope regardless of sex and cigarette smoking.
Conclusions: In individuals with cardiovascular risk factors, evaluation of vascular endothelial function enables prediction of renal prognosis in females and non-smoking males.
掲載誌名
Journal of Atherosclerosis and Thrombosis
ISSN
18803873
13403478
出版者
Japan Atherosclerosis Society
30
11
開始ページ
1727
終了ページ
1741
発行日
2023
備考
内容要旨・審査要旨・論文本文の公開
本論文は,著者Shiho Masudaの学位論文として提出され,学位審査・授与の対象となっている。
権利情報
This article is distributed under the terms of the latest version of CC BY-NC-SA defined by the Creative Commons Attribution License.( https://creativecommons.org/licenses/by-nc-sa/4.0/deed.ja )
EDB ID
出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
博士論文全文を含む
文科省報告番号
甲第3755号
学位記番号
甲医第1580号
学位授与年月日
2023-09-28
学位名
博士(医学)
学位授与機関
徳島大学
部局
医学系
病院
先端酵素学研究所