ID | 103612 |
著者 |
中川, 弘
Pediatric Dentistry, Tokushima University Hospital, University of Tokushima
徳島大学 教育研究者総覧
KAKEN研究者をさがす
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キーワード | Capsaicin
Aoptosis
DNA ladder
Okadaic acid
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資料タイプ |
学術雑誌論文
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抄録 | The aim of this study was to examine whether the neonatal injection of capsaicin induces DNA ladder formation, as an indicator of apoptosis, in the rat trigeminal ganglion (TG). The DNA extracted from the TGs after treatment with capsaicin (50 mg/kg) at 2 days of age exhibited diffuse DNA fragmentation instead of “ladder formation”, as determined by agarose gel electrophoresis. In contrast, clear DNA ladder formation was induced in human osteosarcoma cells treated with okadaic acid (OA) at concentrations of 10 and 20 nM. These results suggest that capsaicin cannot induce apoptosis of TG neurons sufficient for detectable DNA ladder formation. Thus, it is conceivable that capsaicin mainly causes necrosis rather than apoptosis in rodent primary sensory neurons.
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掲載誌名 |
WebmedCentral TOXICOLOGY
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ISSN | 20461690
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出版者 | WebmedCentral
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巻 | 3
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号 | 9
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開始ページ | WMC003708
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発行日 | 2012-09-18
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備考 | Article URL: http://www.webmedcentral.com/article_view/3708
This is an open-access article distributed under the terms of the Creative Commons Attribution License(CC-BY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
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言語 |
eng
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部局 |
病院
歯学系
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