ID | 116140 |
タイトル別表記 | レジストリデータによるがん患者の静脈血栓塞栓症の急性期死亡率
Thromboembolism and Cancer
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著者 |
大櫛, 祐一郎
徳島大学大学院医科学教育部(医学専攻)
Okayama, Yoshihiro
Tokushima University
Zheng, Robert
Tokushima University
Nakai, Michikazu
National Cerebral and Cardiovascular Center
Sumita, Yoko
National Cerebral and Cardiovascular Center
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キーワード | cardio-oncology
mortality
venous thromboembolism
Big data
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資料タイプ |
学位論文
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抄録 | BACKGROUND: The prognosis of patients with cancer-venous thromboembolism (VTE) is not well known because of a lack of registry data. Moreover, there is also no knowledge on how specific types are related to prognosis. We sought to evaluate the clinical characteristics and outcomes of patients with cancer-associated VTE, compared with a matched cohort without cancer using real-world registry data of VTE.
METHODS AND RESULTS: This study was based on the Diagnosis Procedure Combination database in the JROAD-DPC (Japanese Registry of All Cardiac and Vascular Diseases and the Diagnosis Procedure Combination). Of 5 106 151 total patients included in JROAD-DPC, we identified 49 580 patients who were first hospitalized with VTE from April 2012 to March 2017. Propensity score was estimated with a logistic regression model, with cancer as the dependent variable and 18 clinically relevant covariates. After propensity matching, there were 25 148 patients with VTE with or without cancer. On propensity score-matched analysis with 25 148 patients with VTE, patients with cancer had higher total in-hospital mortality within 7 days (1.3% versus 1.1%, odds ratio [OR], 1.66; 95% CI, 1.31–2.11; P<0.0001), 14 days (2.5% versus 1.5%, OR, 2.07; 95% CI, 1.72–2.49; P<0.0001), and 30 days (4.8% versus 2.0%, OR, 2.85; 95% CI, 2.45–3.31; P<0.0001). On analysis for each type of cancer, in-hospital mortality in 11 types of cancer was significantly high, especially pancreas (OR, 12.96; 95% CI, 6.41–26.20), biliary tract (OR, 8.67; 95% CI, 3.00–25.03), and liver (OR, 7.31; 95% CI, 3.05–17.50). CONCLUSIONS: Patients with cancer had a higher in-hospital acute mortality for VTE than those without cancer, especially in pancreatic, biliary tract, and liver cancers. |
掲載誌名 |
Journal of the American Heart Association
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ISSN | 20479980
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出版者 | The American Heart Association
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巻 | 10
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号 | 11
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開始ページ | e019373
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発行日 | 2021-05-22
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備考 | 内容要旨・審査要旨・論文本文の公開
本論文は,著者Yuichiro Okushiの学位論文として提出され,学位審査・授与の対象となっている。 |
権利情報 | © 2021 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/), which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
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EDB ID | |
出版社版DOI | |
出版社版URL | |
フルテキストファイル | |
言語 |
eng
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著者版フラグ |
博士論文全文を含む
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文科省報告番号 | 甲第3531号
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学位記番号 | 甲医第1501号
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学位授与年月日 | 2021-07-29
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学位名 |
博士(医学)
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学位授与機関 |
徳島大学
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部局 |
病院
医学系
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