ID | 116241 |
著者 |
Kojima, Mizuki
Tokushima University
Nishisaka-Nonaka, Risa
Tokushima University
Bui, Thi Kim Ngan
Tokushima University
Wada, Takahiro
Nihon Funen
Okamoto, Masayuki
Nihon Funen
Ito, Hiroshi
Nihon Funen
Tojo, Kenji
Nihon Funen
Daidoji, Tomo
Kyoto Prefectural University of Medicine
Nakaya, Takaaki
Kyoto Prefectural University of Medicine
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キーワード | light emitting diode
ultraviolet
influenza A virus
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資料タイプ |
学術雑誌論文
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抄録 | Influenza A viruses (IAVs) pose a serious global threat to humans and their livestock. This study aimed to determine the ideal irradiation by ultraviolet-light emitting diodes (UV-LEDs) for IAV disinfection. We irradiated the IAV H1N1 subtype with 4.8 mJ/cm2 UV using eight UV-LEDs [peak wavelengths (WL) = 365, 310, 300, 290, 280, 270, and 260 nm)] or a mercury low pressure (LP)-UV lamp (Peak WL = 254 nm). Inactivation was evaluated by the infection ratio of Madin–Darby canine kidney (MDCK) cells or chicken embryonated eggs. Irradiation by the 260 nm UV-LED showed the highest inactivation among all treatments. Because the irradiation-induced inactivation effects strongly correlated with damage to viral RNA, we calculated the correlation coefficient (RAE) between the irradiant spectrum and absorption of viral RNA. The RAE scores strongly correlated with the inactivation by the UV-LEDs and LP-UV lamp. To increase the RAE score, we combined three different peak WL UV-LEDs (hybrid UV-LED). The hybrid UV-LED (RAE = 86.3) significantly inactivated both H1N1 and H6N2 subtypes to a greater extent than 260 nm (RAE = 68.6) or 270 nm (RAE = 42.2) UV-LEDs. The RAE score is an important factor for increasing the virucidal effects of UV-LED irradiation.
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掲載誌名 |
Microorganisms
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ISSN | 20762607
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出版者 | MDPI
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巻 | 8
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号 | 7
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開始ページ | 1014
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発行日 | 2020-07-08
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権利情報 | This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
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EDB ID | |
出版社版DOI | |
出版社版URL | |
フルテキストファイル | |
言語 |
eng
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著者版フラグ |
出版社版
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部局 |
医学系
理工学系
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