ID | 115811 |
著者 |
花岡, 潤
The University of Tokushima
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キーワード | Cholangiolocellular carcinoma
Hepatic stem cells
Combined hepatocellular cholangiocarcinoma
Cancer stem cell marker
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資料タイプ |
学術雑誌論文
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抄録 | Purpose
Cholangiolocellular carcinoma (CLC) is an extremely rare malignant liver tumor. It is thought to originate from the ductules and/or canals of Hering, where hepatic stem cells (HpSC) are located, but there are few reports on cancer stem cell markers in CLC. Thus, we evaluated the significance of cancer stem cell markers, including CD133, CD44, and EpCAM, in CLC. Methods The subjects of this study were three patients with CLC and one patient with an intermediate type of combined hepatocellular cholangiocarcinoma (CHC). The cancer cell markers, CK7, CK19, and EMA, were evaluated immunohistochemically. Results Histological examination of the CLC revealed morphologically cholangiolar features and immunohistochemical examination revealed positivity for CD133, CD44, and EpCAM. On the other hand, in the intermediate type of CHC, only CD44 was positive, whereas CD133 and EpCAM were negative. Conclusion CLC may have stronger features derived from HpSCs than an intermediate type of CHC. |
掲載誌名 |
Surgery Today
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ISSN | 09411291
14362813
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cat書誌ID | AA10824685
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出版者 | Japan Surgical Society|Springer
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巻 | 43
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号 | 6
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開始ページ | 654
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終了ページ | 660
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発行日 | 2012-11-29
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権利情報 | This article is distributed under the terms of the Creative Commons Attribution License(https://creativecommons.org/licenses/by/4.0/) which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited.
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言語 |
eng
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出版社版
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部局 |
病院
医学系
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