ID | 110962 |
タイトル別表記 | 大腸癌肝転移におけるThrombospondin-1発現の役割とその分子メカニズム
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著者 | |
キーワード | 大腸癌
肝転移
THBS-1
HIF-1
EMT
Thrombospondin-1
colorectal liver metastasis
immunohistochemistry
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資料タイプ |
学位論文
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抄録 | Background/Purpose
Thrombospondin-1 (THBS-1), a glycoprotein, is an endogenous inhibitor of angiogenesis and tumor growth. In this study, we investigated the clinical role and mechanism of THBS-1 expression in colorectal liver metastases, focusing on the relationships between its expression and tumor growth, epithelial–mesenchymal transition (EMT), and expression of other relevant molecules. Methods Ninety-four patients who initially underwent curative hepatic resection were enrolled in this study and correlations between expression of THBS-1 (THBS-1 high [n=35] and THBS-1 low [n=59]) and tumor growth, Ki-67 labelling index (Ki-67 LI), expression of other relevant molecules, and microvessel density (MVD) investigated. Results THBS1 low expression correlated with more advanced grade of liver and lymph node metastases and significantly worse overall survival than strong THBS1 expression (3-year survival: 96.7% vs. 65.4%, p<0.01). Multivariate analysis identified THBS1 low expression as an independent prognostic factor (HR=2.82, 95% CI=1.21–7.71, p=0.01). THBS-1 low expression correlated positively with high Ki-67 LI (p<0.05) and inversely with E-cadherin (p<0.05) and hypoxia inducible factor-1α (HIF-1α) expression (p<0.05); THBS-1 expression and MVD were not significantly correlated. Conclusions Low THBS-1 expression may be an independent poor prognostic factor that affects tumor growth and EMT acquisition. Additionally, THBS-1 may be regulated by the HIF-1 pathway. |
掲載誌名 |
Journal of Hepato-Biliary-Pancreatic Sciences
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ISSN | 18686974
18686982
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cat書誌ID | AA12507209
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出版者 | Japanese Society of Hepato‐Biliary‐Pancreatic Surgery|Wily
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巻 | 23
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号 | 9
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開始ページ | 565
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終了ページ | 573
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発行日 | 2016-07-12
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備考 | 内容要旨・審査要旨・論文本文の公開
本論文は, 著者Hiroki Teraokuの学位論文として提出され, 学位審査・授与の対象となっている。 |
EDB ID | |
出版社版DOI | |
出版社版URL | |
フルテキストファイル | |
言語 |
eng
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著者版フラグ |
博士論文全文を含む
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文科省報告番号 | 甲第3118号
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学位記番号 | 甲医第1353号
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学位授与年月日 | 2017-10-26
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学位名 |
博士(医学)
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学位授与機関 |
徳島大学
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部局 |
医学系
病院
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