直近一年間の累計
アクセス数 : ?
ダウンロード数 : ?
ID 117015
タイトル別表記
Biotin levels in blood and follicular fluid
血中および卵胞液中ビオチン濃度と体外受精/顕微授精患者における妊娠転帰との関連について
著者
柳原, 里江 徳島大学大学院医学研究科(医学専攻)
野口, 拓樹 Tokushima University
Yano, Yuya Tokushima University
Hayashi, Noriko Tokushima University
Ohta, Chiaki Tokushima University
鎌田, 周平 Tokushima University
Aoki, Hidenori Tokushima University
Tamura, Kou Tokushima University
Masaki, Rie Tokushima University
Tachibana, Ayaka Tokushima University
新垣, 亮輔 Tokushima University
キーワード
biotin
IVF/ICSI
follicular fluid
pregnancy
資料タイプ
学位論文
抄録
It has been shown that biotin, a water-soluble vitamin (B7), plays roles in reproductive functions, such as oocyte maturation and embryo development, in experimental animals. On the other hand, little is known about the clinical effects of biotin on human reproduction. In this study, serum and follicular fluid biotin levels were measured in patients who underwent in vitro fertilization / intracytoplasmic sperm injection (IVF / ICSI), and their associations with reproductive outcomes were evaluated. As a result, biotin was detected in follicular fluid, as well as serum, and the biotin levels of follicular fluid were found to be positively correlated with those of serum. The biotin levels of serum were higher than those of follicular fluid, suggesting that biotin may be taken up into the follicular fluid from the blood. Although serum and follicular fluid biotin levels tended to be higher in pregnant patients than in non-pregnant patients, these data did not show the significant statistical difference. These findings indicate that biotin does not contribute to the maintenance of oocyte quality, and hence, it does not increase fertilization and pregnancy rates.
掲載誌名
The Journal of Medical Investigation
ISSN
13496867
13431420
cat書誌ID
AA11166929
出版者
Tokushima University Faculty of Medicine
69
1-2
開始ページ
65
終了ページ
69
並び順
65
発行日
2022-02
備考
内容要旨・審査要旨・論文本文の公開
本論文は,著者Rie Yanagiharaの学位論文として提出され,学位審査・授与の対象となっている。
EDB ID
出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
博士論文全文を含む
文科省報告番号
甲第3792号
学位記番号
甲医第1596号
学位授与年月日
2024-03-22
学位名
博士(医学)
学位授与機関
徳島大学
部局
病院
医学系