ID | 110847 |
著者 |
冨岡, 麗子
Department of Internal Medicine and Molecular Therapeutics, Institute of Health Biosciences, The University of Tokushima Graduate School
谷, 憲治
Department of Community and Primary Care Medicine, Institute of Health Biosciences, The University of Tokushima Graduate School
KAKEN研究者をさがす
佐藤, 恵子
Department of Internal Medicine and Molecular Therapeutics, Institute of Health Biosciences, The University of Tokushima Graduate School
鈴鹿, 千幸
Department of Internal Medicine and Molecular Therapeutics, Institute of Health Biosciences, The University of Tokushima Graduate School
豊田, 優子
Department of Internal Medicine and Molecular Therapeutics, Institute of Health Biosciences, The University of Tokushima Graduate School
KAKEN研究者をさがす
岸, 潤
Department of Internal Medicine and Molecular Therapeutics, Institute of Health Biosciences, The University of Tokushima Graduate School
KAKEN研究者をさがす
曽根, 三郎
Department of Internal Medicine and Molecular Therapeutics, Institute of Health Biosciences, The University of Tokushima Graduate School
徳島大学 教育研究者総覧
KAKEN研究者をさがす
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キーワード | systemic lupus erythematosus
exacerbation
lupus nephritis
anti-Sm antibodies
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資料タイプ |
学術雑誌論文
|
抄録 | Systemic lupus erythematosus (SLE) is a chronic disease that is characterized by an undulating course of exacerbations and remissions, and a major determinant of long-term prognosis is organ damage consequent to tissue injury that accompanies disease activity and toxicity of therapy. In this study, we evaluated which patients with SLE will develop an exacerbation and whether factors can be identified to predict the development of an exacerbation. Fifty-seven SLE patients (52 females) were included in this study. The exacerbation of SLE was found in 15 patients (26.3%). A relatively increased incidence of an exacerbation was found in younger SLE patients. An increased percentage of patients who had lupus nephritis at the time of diagnosis of SLE was found in patients with a subsequent exacerbation when compared with that in those without it. Increased incidence of an exacerbation was observed in patients who had decreased number of WBC and platelets, decreased level of C3 and CH50, and the presence positivity of anti-Sm antibodies at the time of the diagnosis. This study suggests that age, renal involvement, and the presence of decreased number of WBC and platelets, decreased level of complements anti-Sm antibodies are predictors of exacerbation.
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掲載誌名 |
The journal of medical investigation : JMI
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ISSN | 13431420
|
cat書誌ID | AA11166929
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巻 | 55
|
号 | 1-2
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開始ページ | 112
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終了ページ | 119
|
並び順 | 112
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発行日 | 2008-02
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EDB ID | |
出版社版DOI | |
出版社版URL | |
フルテキストファイル | |
言語 |
eng
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著者版フラグ |
出版社版
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部局 |
病院
医学系
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