ID | 112399 |
著者 |
Yamamori, Hidenaga
Osaka University
Yasuda, Yuka
Osaka University
Fujimoto, Michiko
Osaka University
Shimodera, Shinji
Kochi Medical School
Nakazawa, Takanobu
Osaka University
Kikuchi, Masataka
Osaka University
Nakaya, Akihiro
Osaka University
Hashimoto, Hitoshi
Osaka University
Hashimoto, Ryota
Osaka University
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キーワード | schizophrenia
DNA methylation
clozapine
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資料タイプ |
学術雑誌論文
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抄録 | Clozapine is an atypical antipsychotic, that is established as the treatment of choice for treatment-resistant schizophrenia (SCZ). To date, no study investigating comprehensive DNA methylation changes in SCZ patients treated with chronic clozapine has been reported. The purpose of the present study is to reveal the effects of clozapine on DNA methylation in treatment-resistant SCZ. We conducted a genome-wide DNA methylation profiling in peripheral leukocytes (485,764 CpG dinucleotides) from treatment-resistant SCZ patients treated with clozapine (n = 21) in a longitudinal study. Significant changes in DNA methylation were observed at 29,134 sites after one year of treatment with clozapine, and these genes were enriched for “cell substrate adhesion” and “cell matrix adhesion” gene ontology (GO) terms. Furthermore, DNA methylation changes in the CREBBP (CREB binding protein) gene were significantly correlated with the clinical improvements. Our findings provide insights into the action of clozapine in treatment-resistant SCZ.
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掲載誌名 |
International Journal of Molecular Sciences
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ISSN | 14220067
16616596
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cat書誌ID | AA12038549
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出版者 | MDPI
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巻 | 18
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号 | 3
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開始ページ | 632
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発行日 | 2017-03-14
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権利情報 | © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
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出版社版DOI | |
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言語 |
eng
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著者版フラグ |
出版社版
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部局 |
病院
医学系
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