ID | 114064 |
著者 |
Iwayama, Yoshimi
RIKEN Brain Science Institute
Toyota, Tomoko
RIKEN Brain Science Institute
Ikeda, Masashi
Fujita Health University
Yamamori, Hidenaga
Osaka University
Shimodera, Shinji
Kochi University
Hashimoto, Ryota
Osaka University
Iwata, Nakao
Fujita Health University
Yoshikawa, Takeo
RIKEN Brain Science Institute
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資料タイプ |
学術雑誌論文
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抄録 | Background: Alterations in one-carbon metabolism have been associated with schizophrenia, and vitamin B6 is one of the key components in this pathway. Methods: We first conducted a case–control study of serum pyridoxal levels and schizophrenia in a large Japanese cohort (n = 1276). Subsequently, we conducted a meta-analysis of association studies (n = 2125). Second, we investigated whether rs4654748, which was identified in a genome-wide association study as a vitamin B6-related single nucleotide polymorphism, was genetically implicated in patients with schizophrenia in the Japanese population (n = 10 689). Finally, we assessed the effect of serum pyridoxal levels on schizophrenia risk using a Mendelian randomization (MR) approach. Results: Serum pyridoxal levels were significantly lower in patients with schizophrenia than in controls, not only in our cohort, but also in the pooled data set of the meta-analysis of association studies (standardized mean difference –0.48, 95% confidence interval [CI] –0.57 to –0.39, p = 9.8 × 10–24). We failed to find a significant association between rs4654748 and schizophrenia. Furthermore, an MR analysis failed to find a causal relationship between pyridoxal levels and schizophrenia risk (odds ratio 0.99, 95% CI 0.65–1.51, p = 0.96). Limitations: Food consumption and medications may have affected serum pyridoxal levels in our cross-sectional study. Sample size, number of instrumental variables and substantial heterogeneity among patients with schizophrenia are limitations of an MR analysis. Conclusion: We found decreased serum pyridoxal levels in patients with schizophrenia in this observational study. However, we failed to obtain data supporting a causal relationship between pyridoxal levels and schizophrenia risk using the MR approach.
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掲載誌名 |
Journal of Psychiatry & Neuroscience
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ISSN | 11804882
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cat書誌ID | AA10850062
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出版者 | Joule
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巻 | 43
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号 | 3
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開始ページ | 194
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終了ページ | 200
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発行日 | 2018-02-06
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権利情報 | Open Access Journal
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EDB ID | |
出版社版DOI | |
出版社版URL | |
フルテキストファイル | |
言語 |
eng
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著者版フラグ |
出版社版
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部局 |
病院
医学系
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