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ID 118188
著者
Tie, Jian Nihon University
Ota, Koya Nihon University
Okuda, Takahisa Nihon University
キーワード
coronary artery disease
microRNA genes
single nucleotide polymorphism
autopsied findings
genotyping
資料タイプ
学術雑誌論文
抄録
Coronary artery disease (CAD) is a common and fatal cardiovascular disease. Among known CAD risk factors, miRNA polymorphisms, such as Has-miR-143 (rs41291957 C>G) and Has-miR-146a (rs2910164 G>A), have emerged as important genetic markers of CAD. Despite many genetic association studies in multiple populations, no study assessing the association between CAD risk and SNPs of miR-143 and miR-146 was documented in the Japanese people. Therefore, using the TaqMan SNP assay, we investigated two SNP genotypes in 151 subjects with forensic autopsy-proven CAD. After pathological observation, we used ImageJ software to assess the degree of coronary artery atresia. Moreover, the genotypes and miRNA content of the two groups of samples with atresia <10% and >10% were analyzed. The results showed that the CC genotype of rs2910164 was more frequent in patients with CAD than in controls, which was associated with the risk of CAD in the study population. However, Has-miR-143 rs41291957 genotype did not show a clear correlation with the risk of CAD.
掲載誌名
Genes
ISSN
20734425
出版者
MDPI
14
2
開始ページ
471
発行日
2023-02-12
権利情報
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
出版社版DOI
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フルテキストファイル
言語
eng
著者版フラグ
出版社版
部局
病院