ID | 118223 |
タイトル別表記 | IKs Block and Spiral-Wave Reentry
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著者 |
Kato, Sara
Nagoya University
Honjo, Haruo
Nagoya University
Takemoto, Yoshio
Nagoya University
Suzuki, Tomoyuki
Nagoya University
Okuno, Yusuke
Nagoya University
Opthof, Tobias
Academic Medical Center|University Medical Center Utrecht
Sakuma, Ichiro
The University of Tokyo
Inada, Shin
National Cardiovascular Center
Nakazawa, Kazuo
National Cardiovascular Center
Ashihara, Takashi
Shiga University of Medical Science
Kodama, Itsuo
Nagoya University
Kamiya, Kaichiro
Nagoya University
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キーワード | β-adrenergic stimulation
IKs
spiral-wave reentry
optical mapping
ventricular tachycardia
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資料タイプ |
学術雑誌論文
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抄録 | We tested a hypothesis that an enhancement of IKs may play a pivotal role in ventricular proarrhythmia under high sympathetic activity. A 2-dimensional ventricular muscle layer was prepared in rabbit hearts, and action potential signals were analyzed by optical mapping. During constant stimulation, isoproterenol (ISP, 0.1 μM) significantly shortened action potential duration (APD); chromanol 293B (30 μM), a selective IKs-blocker, reversed the APD shortening. VTs induced in the presence of ISP lasted longer than in the control, and this was reversed by 293B. E-4031 (0.1 μM), a selective IKr-blocker, did not cause such reversal. Spiral-wave (SW) reentry with ISP was characterized by more stable rotation around a shorter functional block line (FBL) than in the control. After application of 293B, SW reentry was destabilized, and rotation around a longer FBL with prominent drift reappeared. The APD abbreviation by ISP close to the rotation center was more pronounced than in the periphery, leading to an opposite APD gradient (center < periphery) compared with controls. This effect was also reversed by 293B. In conclusion, β-adrenergic stimulation stabilizes SW reentry most likely though an enhancement of IKs. Blockade of IKs may be a promising therapeutic modality in prevention of ventricular tachyarrhythmias under high sympathetic activity.
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掲載誌名 |
Journal of Pharmacological Sciences
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ISSN | 13478613
13478648
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cat書誌ID | AA11806667
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出版者 | Japanese Pharmacological Society|Elsevier
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巻 | 119
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号 | 1
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開始ページ | 52
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終了ページ | 63
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発行日 | 2012-05-17
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権利情報 | © 2012. Production and Hosting by Elseiver B.V. On behalf of Japanese Pharmacological Society.This is an open access article under the CC BY-NC-ND License (https://creativecommons.org/licenses/by-nc-nd/4.0/).
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出版社版DOI | |
出版社版URL | |
フルテキストファイル | |
言語 |
eng
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著者版フラグ |
出版社版
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部局 |
病院
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