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タイトル別表記
IKs Block and Spiral-Wave Reentry
著者
Kato, Sara Nagoya University
Honjo, Haruo Nagoya University
Takemoto, Yoshio Nagoya University
髙成, 広起 Nagoya University|University Medical Center Utrecht 徳島大学 教育研究者総覧
Suzuki, Tomoyuki Nagoya University
Okuno, Yusuke Nagoya University
Opthof, Tobias Academic Medical Center|University Medical Center Utrecht
Sakuma, Ichiro The University of Tokyo
Inada, Shin National Cardiovascular Center
Nakazawa, Kazuo National Cardiovascular Center
Ashihara, Takashi Shiga University of Medical Science
Kodama, Itsuo Nagoya University
Kamiya, Kaichiro Nagoya University
キーワード
β-adrenergic stimulation
IKs
spiral-wave reentry
optical mapping
ventricular tachycardia
資料タイプ
学術雑誌論文
抄録
We tested a hypothesis that an enhancement of IKs may play a pivotal role in ventricular proarrhythmia under high sympathetic activity. A 2-dimensional ventricular muscle layer was prepared in rabbit hearts, and action potential signals were analyzed by optical mapping. During constant stimulation, isoproterenol (ISP, 0.1 μM) significantly shortened action potential duration (APD); chromanol 293B (30 μM), a selective IKs-blocker, reversed the APD shortening. VTs induced in the presence of ISP lasted longer than in the control, and this was reversed by 293B. E-4031 (0.1 μM), a selective IKr-blocker, did not cause such reversal. Spiral-wave (SW) reentry with ISP was characterized by more stable rotation around a shorter functional block line (FBL) than in the control. After application of 293B, SW reentry was destabilized, and rotation around a longer FBL with prominent drift reappeared. The APD abbreviation by ISP close to the rotation center was more pronounced than in the periphery, leading to an opposite APD gradient (center < periphery) compared with controls. This effect was also reversed by 293B. In conclusion, β-adrenergic stimulation stabilizes SW reentry most likely though an enhancement of IKs. Blockade of IKs may be a promising therapeutic modality in prevention of ventricular tachyarrhythmias under high sympathetic activity.
掲載誌名
Journal of Pharmacological Sciences
ISSN
13478613
13478648
cat書誌ID
AA11806667
出版者
Japanese Pharmacological Society|Elsevier
119
1
開始ページ
52
終了ページ
63
発行日
2012-05-17
権利情報
© 2012. Production and Hosting by Elseiver B.V. On behalf of Japanese Pharmacological Society.This is an open access article under the CC BY-NC-ND License (https://creativecommons.org/licenses/by-nc-nd/4.0/).
出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
出版社版
部局
病院