ID | 118205 |
タイトル別表記 | 膵内副脾発生類表皮嚢胞の発生機序・組織学的特徴に関する検討
Histological analysis of ECIPAS
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著者 |
住田, 智志
徳島大学大学院医学研究科(医学専攻)
Miyakami, Yuko
Tokushima University
柿本, 拓海
Tokushima University
小林, 智子
Tokushima University
Taira, Shu
Fukushima University
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キーワード | Epidermoid cyst in intrapancreatic accessory spleen
imaging mass spectrometry
lipid excretion
Pbx1
Tlx1
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資料タイプ |
学位論文
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抄録 | Background : Epidermoid cysts in intrapancreatic accessory spleen (ECIPAS) are a rare lesion. Its pathogenesis, including the origin of cystic epithelium, is not well established. We aimed to elucidate new aspects of the pathological features of ECIPAS to clarify its pathogenesis. Methods : Six cases of ECIPAS were included in this study. As well as histopathological analysis, to elucidate the features and nature of cystic epithelial cells, immunohistochemical analysis including Pbx1 and Tlx1 and imaging mass spectrometry was performed. Results : Histologically, the cysts were covered by either monolayered or multilayered epithelium. Immunohistochemistry revealed that the epithelial cells in multilayered epithelium exhibited different attributes between the basal and superficial layers. Few epithelial cells had abundant clear cytoplasm and were immunohistochemically positive for adipophilin, suggesting lipid-excreting function. The intracystic fluid contained cholesterol clefts and foamy macrophages, and imaging mass spectrometry revealed the accumulation of lipids. Immunohistochemical analysis indicated that the epithelial cells were positive for Pbx1 in some cases. Conclusion : Novel histological features of epithelial cells of ECIPAS were indicated. Although more cases need to be evaluated, we propose that the cause of ECIPAS may be different from that of pancreatic ductal origin.
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掲載誌名 |
The Journal of Medical Investigation
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ISSN | 13496867
13431420
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cat書誌ID | AA11166929
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出版者 | Tokushima University Faculty of Medicine
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巻 | 70
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号 | 1-2
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開始ページ | 251
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終了ページ | 259
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並び順 | 251
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発行日 | 2023-02
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備考 | 内容要旨・審査要旨・論文本文の公開
本論文は,著者Satoshi Sumidaの学位論文として提出され,学位審査・授与の対象となっている。 |
EDB ID | |
出版社版DOI | |
出版社版URL | |
フルテキストファイル | |
言語 |
eng
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著者版フラグ |
博士論文全文を含む
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文科省報告番号 | 甲第3702号
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学位記番号 | 甲医第1572号
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学位授与年月日 | 2023-03-23
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学位名 |
博士(医学)
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学位授与機関 |
徳島大学
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部局 |
医学系
病院
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