ID | 118793 |
タイトル別表記 | DISPENSABLE ROLE OF AIRE IN cDCs
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著者 |
宮澤, 龍一郎
Tokushima University
Nagao, Jun-ichi
Fukuoka Dental College
Arita-Morioka, Ken-ichi
Fukuoka Dental College
Yoshida, Masaki
RIKEN
Yoshida, Hideyuki
RIKEN
Tanaka, Yoshihiko
Fukuoka Dental College
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資料タイプ |
学術雑誌論文
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抄録 | Aire, the defect of which is responsible for the development of autoimmunity, is predominantly expressed in medullary thymic epithelial cells, and it controls a wide variety of genes, including those of tissue-restricted Ags, for establishing thymic tolerance. Aire is also expressed from APCs in the periphery, called extrathymic Aire-expressing cells (eTACs), and their complementing role to thymic tolerance has been suggested. eTACs are composed of two distinct classes of APCs, conventional dendritic cell (cDC)–type and group 3 innate lymphoid cell (ILC3)-like–type expressing retinoic acid receptor–related orphan receptor γt (RORγt). Although the essential role of Aire in the latter in the Th17-mediated immune response against Candida albicans has been reported, the role of Aire in the cDC-type eTACs for this action has not been examined. Furthermore, the significance of Aire in the production of the transcriptome of the cDC-type eTACs remains unknown. We have approached these issues using a high-fidelity Aire-reporter mouse strain. We found that although the cDC-type eTACs dominated ILC3-like–type eTACs in number and they served as efficient APCs for the immune response against an exogenous Ag as well as for the C. albicans–specific Th17 immune response, loss of Aire in cDC-type eTACs showed no clear effect on these functions. Furthermore, loss of Aire showed no major impact on the transcriptome from cDC-type eTACs. These results suggested that Aire in cDC-type eTACs may not have a cell-intrinsic role in the immune response in contrast to the role of Aire in ILC3-like–type eTACs.
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掲載誌名 |
ImmunoHorizons
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ISSN | 25737732
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出版者 | The American Association of Immunologists
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巻 | 7
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号 | 1
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開始ページ | 140
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終了ページ | 158
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発行日 | 2023-01-25
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権利情報 | This article is distributed under the terms of the CC BY-NC-ND 4.0 Unported license (https://creativecommons.org/licenses/by-nc-nd/4.0/).
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言語 |
eng
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著者版フラグ |
出版社版
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部局 |
先端酵素学研究所
医学系
病院
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