直近一年間の累計
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ID 118015
著者
Minato, Masanori Tokushima University
村上, 太一 Tokushima University|Ehime Prefectural Central Hospital KAKEN研究者をさがす
Takahashi, Naoki University of Fukui
小野, 広幸 Tokushima University
西村, 賢二 Tokushima University
Iwano, Masayuki University of Fukui
Joh, Kensuke The Jikei University School of Medicine
キーワード
tubulointerstitial nephritis with IgM-positive plasma cells
intracellular crystalline inclusions in the rough endoplasmic reticulum
glucocorticoid dependence
資料タイプ
学術雑誌論文
抄録
Tubulointerstitial nephritis (TIN) with IgM-positive plasma cells (IgMPC-TIN) is an autoimmune kidney disease characterized by IgM/CD138-double-positive plasma cell infiltration in the tubulointerstitium. A 50-year-old man developed IgMPC-TIN and presented with crystalline inclusions in the rough endoplasmic reticulum. Intracellular crystal formation is a rare finding in paraprotein-related kidney diseases, but this case showed no pathogenic monoclonal immunoglobulin. Prednisolone (PSL, 30 mg) improved the TIN, but PSL tapering resulted in the recurrence of TIN. Combination therapy with 15 mg PSL and 150 mg mizoribine ultimately stabilized TIN. This case offers original evidence concerning the pathophysiology and treatment strategy of IgMPC-TIN.
掲載誌名
Internal Medicine
ISSN
13497235
出版者
The Japanese Society of Internal Medicine
60
19
開始ページ
3129
終了ページ
3136
発行日
2021-10-01
権利情報
The Internal Medicine is an Open Access journal distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
EDB ID
出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
出版社版
部局
医学系
病院