ID | 114104 |
タイトル別表記 | Vitamin B6 and schizophrenia
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著者 | |
キーワード | Schizophrenia
Vitamin B6
Pyridoxal
Mendelian randomization
One-carbon metabolism
Homocysteine
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資料タイプ |
学術雑誌論文
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抄録 | Accumulating evidence indicates that alterations in one-carbon metabolism may play an important role in the pathogenesis of schizophrenia. We focused on vitamin B6 (pyridoxal), which works as a coenzyme in one-carbon metabolism. We first conducted a case-control study and demonstrated that serum pyridoxal levels were significantly lower in the schizophrenia group than in the control group. Subsequently, we conducted a meta-analysis of case-control studies and achieved the similar result to the case-control study. Finally, we investigated the causality between serum pyridoxal levels and schizophrenia by a Mendelian randomization analysis. However, we could indicate no significant causality between serum pyridoxal levels and schizophrenia in the Japanese population. Further studies such as a longitudinal study will be needed because there are several studies on the benefits of vitamin B6 in schizophrenia.
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掲載誌名 |
ビタミン
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ISSN | 0006386X
2424080X
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cat書誌ID | AA11693298
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出版者 | 日本ビタミン学会
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巻 | 92
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号 | 10
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開始ページ | 450
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終了ページ | 456
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発行日 | 2018-10-25
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EDB ID | |
出版社版DOI | |
出版社版URL | |
フルテキストファイル | |
言語 |
jpn
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著者版フラグ |
出版社版
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部局 |
病院
医学系
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