ID | 109607 |
タイトルヨミ | カンセン チリョウ ニ アタラシイ ジダイ ノ マクアケ : セイブツガクテキ セイザイ
|
タイトル別表記 | The opening of a new age in the treatment of psoriasis : Biologics
|
著者 | |
キーワード | psoriasis
TNF-α
Interleukin12/23
biologics
|
資料タイプ |
学術雑誌論文
|
抄録 | Psoriasis is a chronic inflammatory skin disease, which is clinically characterized by scaly erythemas on the whole body. In the fully developed lesions of psoriasis, the histological features have demonstrated epidermal hyperproliferation with infiltration of T lymphocytes in the dermal papillae. Although pre-biological systemic therapies has targeted mainly proliferative keratinocytes and activated T cells, their effects were limited or these therapies could not be applied for patients with severe organ failures. Therefore, more effective agents are expected to improve quality of life (QOL) of patients with psoriasis. Recent studies have showed what kinds of cells, cell surface molecules, and cytokines should play a pivotal role in the pathogenesis of psoriasis. Biological therapies targeting these molecules have proved to be so effective for obstinate lesions of psoriasis. Here, we describe clinical features and pathogenesis of psoriasis, and the characteristics of several conventional and biological therapies for psoriasis in Japan.
|
掲載誌名 |
四国医学雑誌
|
ISSN | 00373699
|
cat書誌ID | AN00102041
|
出版者 | 徳島医学会
|
巻 | 69
|
号 | 1-2
|
開始ページ | 3
|
終了ページ | 6
|
並び順 | 3
|
発行日 | 2013-04-25
|
EDB ID | |
フルテキストファイル | |
言語 |
jpn
|
著者版フラグ |
出版社版
|
部局 |
医学系
病院
|