直近一年間の累計
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ID 118599
著者
曽我部, 正弘 Tokushima University|Shikoku Central Hospital of the Mutual Aid Association of Public School Teachers 徳島大学 教育研究者総覧 KAKEN研究者をさがす
岡久, 稔也 Tokushima University|Shikoku Central Hospital of the Mutual Aid Association of Public School Teachers 徳島大学 教育研究者総覧 KAKEN研究者をさがす
香川, 美和子 Shikoku Central Hospital of the Mutual Aid Association of Public School Teachers
上田, 浩之 Tokushima University|Shikoku Central Hospital of the Mutual Aid Association of Public School Teachers
影本, 開三 Tokushima University
Nakasono, Masahiko Tsurugi Municipal Handa Hospital
キーワード
Ages
Alcohol drinking
Onset
Liver diseases
Sex
資料タイプ
学術雑誌論文
抄録
Background & aims: The influence of changes in alcohol consumption on newly developed metabolic dysfunction-associated fatty liver disease (MAFLD) is unclear. We investigated the influence of alcohol consumption on newly developed MAFLD in both sexes.
Methods: This observational cohort study included 4071 patients who underwent more than two health check-ups between 2015 and 2020 over an interval of more than a year. Generalised estimating equations were used for analyses.
Results: At baseline, the rates of drinking and MAFLD between men and women were 72.5% versus 41.7% and 42.2% versus 22.1%, respectively. At the most recent stage, the rates of an increase in alcohol consumption for men and women were 13.3% and 8.7%, respectively, and 311/1192 (26.1%) men and 155/1566 (9.9%) women had newly developed MAFLD. The odds ratio (OR) for drinking in patients with newly developed MAFLD was 0.863 (men) (95% confidence interval [CI], 0.676-1.102, p = 0.237) and 1.041 (women) (95% CI, 0.753-1.439, p = 0.808); the OR for women who drank 140-279.9 g/week was 2.135 (95% CI, 1.158-3.939, p < 0.05) and that for all drinking categories among women was >1. Several non-invasive fibrosis scores were significantly associated with the quantity of alcohol consumption in patients with newly developed MAFLD (p < 0.005).
Conclusions: Alcohol consumption had no significant protective effect against newly developed MAFLD in both sexes, regardless of quantity. Conversely, alcohol consumption ≥140 g/week was a risk factor for newly developed MAFLD in women. The development of liver fibrosis with increased alcohol intake should be considered in patients with MAFLD.
掲載誌名
Clinical Nutrition
ISSN
15321983
02615614
cat書誌ID
AA11544924
AA10643818
出版者
Elsevier
42
5
開始ページ
810
終了ページ
816
発行日
2023-03-31
権利情報
This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
EDB ID
出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
出版社版
部局
医学系
病院