ID | 115067 |
著者 |
Nakazeki, Fumiko
Kyoto University
Tsuge, Itaru
Kyoto University
Horie, Takahiro
Kyoto University
Imamura, Keiko
Kyoto University|RIKEN BioResource Center|RIKEN Center for Advanced Intelligence Project
Tsukita, Kayoko
Kyoto University|RIKEN BioResource Center
Hotta, Akitsu
Kyoto University
Baba, Osamu
Kyoto University
Kuwabara, Yasuhide
Kyoto University
Nishino, Tomohiro
Kyoto University
Nakao, Tetsushi
Kyoto University
Nishiga, Masataka
Kyoto University
Nishi, Hitoo
Kyoto University
Nakashima, Yasuhiro
Kyoto University
Ide, Yuya
Kyoto University
Koyama, Satoshi
Kyoto University
Kimura, Masahiro
Kyoto University
Tsuji, Shuhei
Kyoto University
Naitoh, Motoko
Kyoto University
Suzuki, Shigehiko
Kyoto University
Kimura, Takeshi
Kyoto University
Inoue, Haruhisa
Kyoto University|RIKEN BioResource Center|RIKEN Center for Advanced Intelligence Project
Ono, Koh
Kyoto University
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資料タイプ |
学術雑誌論文
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抄録 | Recent reports, including ours, have indicated that microRNA (miR)-33 located within the intron of sterol regulatory element binding protein (SREBP) 2 controls cholesterol homeostasis and can be a potential therapeutic target for the treatment of atherosclerosis. Here, we show that SPAST, which encodes a microtubule-severing protein called SPASTIN, was a novel target gene of miR-33 in human. Actually, the miR-33 binding site in the SPAST 3′-UTR is conserved not in mice but in mid to large mammals, and it is impossible to clarify the role of miR-33 on SPAST in mice. We demonstrated that inhibition of miR-33a, a major form of miR-33 in human neurons, via locked nucleic acid (LNA)-anti-miR ameliorated the pathological phenotype in hereditary spastic paraplegia (HSP)-SPG4 patient induced pluripotent stem cell (iPSC)-derived cortical neurons. Thus, miR-33a can be a potential therapeutic target for the treatment of HSP-SPG4.
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掲載誌名 |
Clinical Science
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ISSN | 01435221
14708736
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cat書誌ID | AA00143386
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出版者 | Portland Press
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巻 | 133
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号 | 4
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開始ページ | 583
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終了ページ | 595
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発行日 | 2019-02-22
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権利情報 | This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY-NC-ND)(https://creativecommons.org/licenses/by-nc-nd/4.0/).
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EDB ID | |
出版社版DOI | |
出版社版URL | |
フルテキストファイル | |
言語 |
eng
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著者版フラグ |
出版社版
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部局 |
病院
医学系
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