直近一年間の累計
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ID 118076
著者
梶, 龍兒 Tokushima University|National Hospital Organization Utano Hospital 徳島大学 教育研究者総覧 KAKEN研究者をさがす
Furumoto, Taiki Tokushima University
Takeuchi, Toshiaki Tokushima University|National Hospital Organization Utano Hospital
Kohda, Tomoko Osaka Metropolitan University
Kozaki, Shunji Osaka Metropolitan University
キーワード
botulinum neurotoxin
subtype A2
A2NTX
onabotulinumtoxinA
clinical efficacy
safety
spasticity: modified Ashworth scale
Functional Independence Measure
hand grip
spread
資料タイプ
学術雑誌論文
抄録
All the currently used type A botulinum neurotoxins for clinical uses are of subtype A1. We compared the efficacy and safety for the first time head-to-head between a novel botulinum toxin A2NTX prepared from subtype A2 and onabotulinumtoxinA (BOTOX) derived from A1 for post-stroke spasticity. We assessed the modified Ashworth scale (MAS) of the ankle joint, the mobility scores of Functional Independence Measure (FIM), and the grip power of the unaffected hand before and after injecting 300 units of BOTOX or A2NTX into calf muscles. The procedure was done in a blinded manner for the patient, the injecting physician, and the examiner. Stroke patients with chronic spastic hemiparesis (15 for A2NTX and 16 for BOTOX) were enrolled, and 11 for A2NTX and 13 for BOTOX (MAS of ankle; > or = 2) were entered for the MAS study. Area-under-curves of changes in MAS (primary outcome) were greater for A2NTX by day 30 (p = 0.044), and were similar by day 60. FIM was significantly improved in the A2NTX group (p = 0.005), but not in the BOTOX group by day 60. The hand grip of the unaffected limb was significantly decreased in the BOTOX-injected group (p = 0.002), but was unaffected in the A2NTX-injected group by day 60, suggesting there was less spread of A2NTX to the upper limb than there was with BOTOX. Being a small-sized pilot investigation with an imbalance in the gender of the subjects, the present study suggested superior efficacy and safety of A2NTX, and warrants a larger scale clinical trial of A2NTX to confirm these preliminary results.
掲載誌名
Toxins
ISSN
20726651
出版者
MDPI
14
11
開始ページ
739
発行日
2022-10-28
権利情報
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
EDB ID
出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
出版社版
部局
医学系
病院