ID | 116770 |
タイトル別表記 | PETを用いたレディオミクス解析による舌扁平上皮癌の頸部リンパ節転移の予測
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著者 | |
キーワード | Tongue squamous cell carcinoma
Cervical lymph node metastasis
Radiomics
[18F]-fluoro-2-deoxyglucose
Positron emission tomography
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資料タイプ |
学位論文
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抄録 | Objectives
This study aimed to create a predictive model for cervical lymph node metastasis (CLNM) in patients with tongue squamous cell carcinoma (SCC) based on radiomics features detected by [18F]-fluoro-2-deoxyglucose (18F-FDG) positron emission tomography (PET). Methods A total of 40 patients with tongue SCC who underwent 18F-FDG PET imaging during their first medical examination were enrolled. During the follow-up period (mean 28 months), 20 patients had CLNM, including six with late CLNM, whereas the remaining 20 patients did not have CLNM. Radiomics features were extracted from 18F-FDG PET images of all patients irrespective of metal artifact, and clinicopathological factors were obtained from the medical records. Late CLNM was defined as the CLNM that occurred after major treatment. The least absolute shrinkage and selection operator (LASSO) model was used for radiomics feature selection and sequential data fitting. The receiver operating characteristic curve analysis was used to assess the predictive performance of the 18F-FDG PET-based model and clinicopathological factors model (CFM) for CLNM. Results Six radiomics features were selected from LASSO analysis. The average values of the area under the curve (AUC), accuracy, sensitivity, and specificity of radiomics analysis for predicting CLNM from 18F-FDG PET images were 0.79, 0.68, 0.65, and 0.70, respectively. In contrast, those of the CFM were 0.54, 0.60, 0.60, and 0.60, respectively. The 18F-FDG PET-based model showed significantly higher AUC than that of the CFM. Conclusions The 18F-FDG PET-based model has better potential for diagnosing CLNM and predicting late CLNM in patients with tongue SCC than the CFM. |
掲載誌名 |
Oral Radiology
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ISSN | 09116028
16139674
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cat書誌ID | AA10689728
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出版者 | Japanese Society for Oral and Maxillofacial Radiology|Springer Nature
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巻 | 39
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号 | 1
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開始ページ | 41
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終了ページ | 50
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発行日 | 2022-03-07
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備考 | 内容要旨・審査要旨・論文本文の公開
本論文は,著者Takaharu Kudohの学位論文として提出され,学位審査・授与の対象となっている。 This version of the article has been accepted for publication, after peer review (when applicable) and is subject to Springer Nature’s AM terms of use (https://www.springernature.com/gp/open-research/policies/accepted-manuscript-terms), but is not the Version of Record and does not reflect post-acceptance improvements, or any corrections. The Version of Record is available online at: http://dx.doi.org/10.1007/s11282-022-00600-7 |
EDB ID | |
出版社版DOI | |
出版社版URL | |
フルテキストファイル | |
言語 |
eng
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著者版フラグ |
博士論文全文を含む
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文科省報告番号 | 甲第3643号
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学位記番号 | 甲口第487号
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学位授与年月日 | 2022-07-15
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学位名 |
博士(歯学)
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学位授与機関 |
徳島大学
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部局 |
歯学系
医学系
病院
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