| ID | 114392 |
| 著者 |
Ooguro, Yukari
Tokushima University
森本, 佳奈
Tokushima University
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| キーワード | hypothalamic-pituitary-adrenal axis
adrenal insufficiency
chlormadinone acetate
prostate cancer
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| 資料タイプ |
学術雑誌論文
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| 抄録 | A 78-year-old Japanese man showed suppression of the hypothalamic-pituitary-adrenal axis during maximum androgen blockade (MAB) therapy including chlormadinone acetate (CMA) for prostate cancer. After stopping the MAB therapy, both the basal ACTH level and the response to CRH recovered. While no reports have indicated that CMA suppresses the hypothalamic-pituitary-adrenal axis in patients with prostate cancer, CMA has been shown to inhibit this axis in animals. These observations suggest that we must monitor the hypothalamic-pituitary-adrenal axis in patients treated with CMA, especially under stressful conditions.
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| 掲載誌名 |
Internal Medicine
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| ISSN | 13497235
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| 出版者 | The Japanese Society of Internal Medicine
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| 巻 | 55
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| 号 | 24
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| 開始ページ | 3623
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| 終了ページ | 3626
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| 発行日 | 2016-12-15
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| 権利情報 | The Internal Medicine is an Open Access article distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
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| 言語 |
eng
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| 著者版フラグ |
出版社版
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| 部局 |
病院
医学系
先端酵素学研究所
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