直近一年間の累計
アクセス数 : ?
ダウンロード数 : ?
ID 118610
タイトル別表記
Systemic amyloidosis by LPL
著者
Hori, Taiki Anan Medical Center|Tokushima University
Yasui, Saya Anan Medical Center
Hosoki, Minae Anan Medical Center
山上, 紘規 Anan Medical Center|Tokushima University 徳島大学 教育研究者総覧
乙田, 敏城 Tokushima University
Takishita, Makoto Anan Medical Center
Yokohama, Akihiko Gunma University
Ueda, Mitsuharu Kumamoto University
キーワード
lymphoplasmacytic lymphoma
amyloidosis
rituximab
資料タイプ
学術雑誌論文
抄録
We present the case of an 81-year-old woman with right shoulder discomfort and right supraclavicular lymph node swelling who referred to our hospital. Blood tests results showed normal immunoglobulin levels, but free light chain assay showed abnormal κ/λ ratio. Serum immunoelectrophoresis detected immunoglobulin G-λ type M proteins. 18F-fluorodeoxyglucose computed tomography revealed swelling of the right supraclavicular and mediastinal lymph nodes. Biopsy of the right supraclavicular lymph node showed a mixture of small lymphocytes with plasma cell-like round cells that were positive for cell surface CD20, CD138, CD56, IgG and λ, and negative for transthyretin and amyloid A. They had a Congo red stain-positive, glass-like surrounding structure and apple-green birefringence was observed under polarized light. Duodenal, gastric, and skin biopsies also showed amyloid deposits. We diagnosed the patient with lymphoplasmacytic lymphoma complicated by systemic light-chain amyloidosis. Rituximab monotherapy led to complete metabolic response. Systemic amyloidosis is a rare complication of B-cell lymphoma; however, the possibility of amyloidosis should be considered, even in patients with lymphadenopathy.
掲載誌名
International Journal of Myeloma
ISSN
21873143
cat書誌ID
AA12766965
出版者
Japanese Society of Myeloma
13
2
開始ページ
7
終了ページ
12
発行日
2023
EDB ID
出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
出版社版
部局
病院
医学系