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ID 119161
タイトル別表記
成長ホルモンシグナルにおけるα-klothoの関与
著者
小池, 萌 徳島大学大学院医科栄養学研究科(医科栄養学専攻)
Sato, Tetsuhiko Nagoya Daini Red Cross Hospital
Komiya, Aoi Tokushima University
Miura, Mizuki Tokushima University
Higashi, Ayami Tokushima University
Ishikawa, Akane Tokushima University
Takayanagi, Kaori Tokushima University
Uga, Minori Tokushima University
キーワード
growth hormone
α-klotho
kidney
CKD
GH-resistant
資料タイプ
学位論文
抄録
Growth hormone (GH) exerts multiple effects on different organs directly or via its main mediator, insulin-like growth factor1 (IGF1). In this study, we focused on the novel relationship between GH action and the antiaging hormone α-klotho. Immunofluorescent staining of α-klotho was observed in the renal distal tubules and pituitary glands of somatostatin- and GH-positive cells in wild-type (WT) mice. Treatment of 4-week-old WT mice with GH increased IGF1 mRNA expression in the pituitary gland, liver, heart, kidney, and bone but increased α-klotho mRNA expression only in the pituitary gland, kidney, and bone. Increased α-klotho protein levels were observed in the kidney but not in the pituitary gland. No induction of α-klotho RNA expression by GH was observed in juvenile mice with kidney disease, indicating GH resistance. Furthermore, GH and α-klotho supplementation in HEK293 cells transfected with GHR increased Janus kinase 2 mRNA (a GH downstream signal) expression compared to supple­mentation with GH alone. In conclusion, we suggest that 1) the kidney is the main source of secreted α-klotho, which is detected in blood by the downstream action of GH, 2) α-klotho induction by GH is resistant in kidney disease, and 3) α-klotho might be an enhanced regulator of GH signaling.
掲載誌名
Journal of Clinical Biochemistry and Nutrition
ISSN
09120009
18805086
cat書誌ID
AA10710201
出版者
Society for Free Radical Research Japan
74
3
開始ページ
221
終了ページ
229
発行日
2024
備考
内容要旨・審査要旨・論文本文の公開
本論文は,著者Megumi Koikeの学位論文として提出され,学位審査・授与の対象となっている。
権利情報
This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (https://creativecommons.org/licenses/by-nc-nd/4.0/).
EDB ID
出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
博士論文全文を含む
文科省報告番号
甲第3775号
学位記番号
甲栄第303号
学位授与年月日
2024-02-22
学位名
博士(栄養学)
学位授与機関
徳島大学
部局
医学系