ID | 83622 |
著者 |
宮本, 賢一
Department of Nutritional Science, The University of Tokushima School of Medicine
徳島大学 教育研究者総覧
KAKEN研究者をさがす
イトウ, ミキコ
Department of Nutritional Science, The University of Tokushima School of Medicine
瀬川, 博子
Department of Nutritional Science, The University of Tokushima School of Medicine
徳島大学 教育研究者総覧
KAKEN研究者をさがす
クワハタ, マサシ
Department of Nutritional Science, The University of Tokushima School of Medicine
|
キーワード | parathyroid
phosphate
transporter
secondary hyperparathyroidism
vitamin D
|
資料タイプ |
学術雑誌論文
|
抄録 | Retention of inorganic phosphate (Pi) and associated hyperphosphatemia are important in the development of hyperparathyroidism secondary to renal failure. The beneficial effect of a low-Pi diet in the prevention of hyperparathyroidism can be attributed to the decrease in PTH secretion. This effect of Pi may be mediated by specific molecules in the parathyroid cell membrane. A complementary DNA encoding a Na+-Pi co-transporter, termed rat PiT-1, has been isolated from rat parathyroid. The amount of PiT-1 mRNA in the parathyroid is controlled by vitamin D and dietary Pi, which are the most important regulators of PTH secretion. The parathyroid Pi transporter may mediate the effects of extracellular Pi and PTH secretion in secondary hyperparathyroidism. In this study, we focus on the function of Na/Pi co-transporters in the parathyroid glands as inorganic Pi sensor.
|
掲載誌名 |
The journal of medical investigation : JMI
|
ISSN | 13431420
|
cat書誌ID | AA11166929
|
巻 | 47
|
号 | 3-4
|
開始ページ | 118
|
終了ページ | 122
|
並び順 | 118
|
発行日 | 2000
|
備考 | |
フルテキストファイル | |
言語 |
eng
|
部局 |
医学系
|