ID | 109552 |
著者 |
タグチ, カヨ
Department of Clinical Nutrition, Institute of Health Biosciences, University of Tokushima Graduate School
(山中)奥村, 仙示
Department of Clinical Nutrition, Institute of Health Biosciences, University of Tokushima Graduate School
KAKEN研究者をさがす
ミズノ, アキラ
Department of Clinical Biology and Medicine, Institute of Health Biosciences,University of Tokushima Graduate School
ナカムラ, タキ
Department of Clinical Nutrition, Institute of Health Biosciences, University of Tokushima Graduate School
島田, 光生
Department of Digestive and Pediatric Surgery, Institute of Health Biosciences, University of Tokushima Graduate School
徳島大学 教育研究者総覧
KAKEN研究者をさがす
土井, 俊夫
Department of Clinical Biology and Medicine, Institute of Health Biosciences,University of Tokushima Graduate School
徳島大学 教育研究者総覧
KAKEN研究者をさがす
武田, 英二
Department of Clinical Nutrition, Institute of Health Biosciences, University of Tokushima Graduate School
徳島大学 教育研究者総覧
KAKEN研究者をさがす
|
キーワード | nutritional assessment
liver cirrhosis
hyperinsulinemic euglycemic clamp combined with oral glucose load
indirect calorimetry
diabetes mellitus
|
資料タイプ |
学術雑誌論文
|
抄録 | Glucose intolerance characterized by postprandial hyperglycemia and hyperinsulinemia
is commonly seen in patients with liver cirrhosis (LC). The aim of this study is to clarify the relation between glucose intolerance and disorder of liver function in patients with LC. The 75 g oral glucose tolerance test (75 g OGTT) and the hyperinsulinemic euglycemic clamp combined with 0.2 g/kg oral glucose load (HECGL) were conducted in 61 patients with LC. Based on the results of 75 g OGTT, the 61 patientswith LCwere divided into groups, 21 (34.4%) patients with normal glucose tolerance (LC-NGT), 12 (19.7%) patients with impaired glucose tolerance (LC-IGT) and 28 (45.9%) patients with diabetes mellitus (LC-DM). Fasting plasma glucose (FPG) level was normal in 50 (82.0%) patients with LC. All patients with LC showed insulin resistance in both peripheral (skeletal and adipose) and hepatic tissues evaluated by HECGL, although significant correlation between the degree of glucose intolerance and the severity of hepatic dysfunction was not observed. Insulin resistance in both liver and peripheral tissues is the early sign in the patients with LC. This fact indicates that nutritional care from early stages of LC would be necessary in the patients. |
掲載誌名 |
The journal of medical investigation : JMI
|
ISSN | 13431420
|
cat書誌ID | AA11166929
|
巻 | 61
|
号 | 1-2
|
開始ページ | 180
|
終了ページ | 189
|
並び順 | 180
|
発行日 | 2014-02
|
EDB ID | |
出版社版DOI | |
出版社版URL | |
フルテキストファイル | |
言語 |
eng
|
著者版フラグ |
出版社版
|
部局 |
医学系
|