ID | 98233 |
タイトルヨミ | コウウンドウセイ モデル ラット SPORTS ノ カイバ ニオケル ノルエピネフリン ドウタイ ト ジハツ ウンドウリョウ
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タイトル別表記 | Hippocampal norepinephrine level and exercise behavior in SPORTS rats
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著者 |
森島, 真幸
徳島大学大学院ヘルスバイオサイエンス研究部医療栄養科学講座代謝栄養学分野
原, 小由合
徳島大学大学院ヘルスバイオサイエンス研究部医療栄養科学講座代謝栄養学分野
佐野, 敦子
徳島大学大学院ヘルスバイオサイエンス研究部情報統合医学講座統合生理学分野
妹尾, 廣正
徳島大学大学院ヘルスバイオサイエンス研究部情報統合医学講座統合生理学分野
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キーワード | exercise behavior
hyper-running
monoamine oxidase A
norepinephrine
hippocampus
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資料タイプ |
学術雑誌論文
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抄録 | Reduced physical exercise activity contributes to the development of several metabolic disorders including obesity, type 2 diabetes and hypertension. Especially in the developed countries, many people choose not to be active physically, possibly because of a reduced motivation to participate in exercise activities. Thus, augmentation of exercise motivation and subsequent increase in the physical activity would reduce an incidence of these metabolic disorders. In order to clarify the psychological mechanisms responsible for an increased exercise activity, we have generated and established a line of SPORTS (Spontaneously-Running-Tokushima-Shikoku) rat for high levels of voluntary wheel running. Male SPORTS rats run voluntarily in the running wheel almost six times longer than control Wistar rats. Here we examined the relation of the running activity of SPORTS rat with the hippocampal norepinephrine (NE) system including the levels of NE, adrenergic receptors, and degradation enzymes for monoamines. In the hippocampus of SPORTS rats, the level of NE in extracellular fluid was augmented, whereas the level in the homogenate of the whole tissue was decreased even for sedentary conditions. The level of striatal dopamine has not altered in both groups. The protein expression and the activity levels of monoamine oxidase A (MAOA), a critical enzyme for the degaradation of NE, were decreased in the hippocampus of SPORTS rats to increase extracellular NE level. Thus, inhibition of oxidase activity in normal Wistar rats markedly increased wheel running activity. Our results indicate that the hippocampal NE determines the neural basis of the psychological regulation of exercise behavior in SPORTS rats. Modulation of NE transmission in the hippocampus will be a good method for enhancing the exercise behavior both in clinical patients and in healthy humans.
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掲載誌名 |
四国医学雑誌
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ISSN | 00373699
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cat書誌ID | AN00102041
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出版者 | 徳島医学会
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巻 | 61
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号 | 5-6
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開始ページ | 185
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終了ページ | 188
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並び順 | 185
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発行日 | 2005-12-20
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備考 | |
EDB ID | |
フルテキストファイル | |
言語 |
jpn
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部局 |
医学系
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