直近一年間の累計
アクセス数 : ?
ダウンロード数 : ?
ID 117712
タイトル別表記
新規PCOSラットモデルの作製とその生殖・代謝・行動表現型の評価
著者
鎌田, 周平 徳島大学大学院医学研究科(医学専攻)
Aoki, Hidenori Tokushima University
Tamura, Kou Tokushima University
Takeda, Asuka Tokushima University
Masaki, Rie Tokushima University
Yanagihara, Rie Tokushima University
Hayashi, Noriko Tokushima University
Yano, Yuya Tokushima University
今泉, 絢貴 Tokushima University
キーワード
activity
DHT
metabolic
PCOS
reproduction
資料タイプ
学位論文
抄録
Background: Although animal models of PCOS have been used in many studies, none of them can reproduce both the reproductive and metabolic phenotypes of PCOS. In addition, behavioral parameters have not been evaluated in PCOS animal models.
Purpose: We tried to produce an improved rat model of PCOS, and the reproductive, metabolic, and behavioral phenotypes of the model rats were evaluated.
Methods: Female rats were implanted with silicon tubes containing oil-dissolved dihydrotestosterone (Oil-DHT) as a new PCOS model. Their phenotypes were compared with those of conventional PCOS model rats (DHT), into which tubes containing crystalline DHT were implanted, and non-DHT-treated rats (control).
Results: Both the Oil-DHT and DHT rats showed greater body weight gain, food intake, and fat depot weight than the control rats. Furthermore, these groups showed fewer estrous stages and increased numbers of cystic follicles. The DHT rats exhibited lower ovarian and uterine weights than the control rats, whereas no such changes were observed in the Oil-DHT rats. The Oil-DHT and DHT rats showed less locomotor activity in the light phase than the control rats.
Conclusions: Our proposed PCOS model reproduced both the reproductive and metabolic phenotypes of PCOS and may have potential for PCOS research.
掲載誌名
Reproductive Medicine and Biology
ISSN
14470578
cat書誌ID
AA11706516
出版者
Japan Society for Reproductive Medicine|John Wiley & Sons
21
1
開始ページ
e12416
発行日
2021-10-02
備考
内容要旨・審査要旨・論文本文の公開
本論文は,著者Shuhei Kamadaの学位論文として提出され,学位審査・授与の対象となっている。
権利情報
This is an open access article under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
EDB ID
出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
博士論文全文を含む
文科省報告番号
甲第3796号
学位記番号
甲医第1602号
学位授与年月日
2024-03-22
学位名
博士(医学)
学位授与機関
徳島大学
部局
病院
医学系