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ID 111302
著者
湯浅, 志乃 The University of Tokushima
山口, 治隆 The University of Tokushima KAKEN研究者をさがす
中西, 嘉憲 The University of Tokushima
河南, 真吾 The University of Tokushima
田畑, 良 The University of Tokushima KAKEN研究者をさがす
清水, 伸彦 The University of Tokushima
河野, 光宏 The University of Tokushima
Shimizu, Teruki Toyo Hospital
Miyata, Junya Miyoshi Municipal Mino Hospital
Nakayama, Mayuko Hanoura Hospital of Orthopedics and Internal Medicine
岸, 潤 The University of Tokushima KAKEN研究者をさがす
豊田, 優子 The University of Tokushima KAKEN研究者をさがす
谷, 憲治 The University of Tokushima KAKEN研究者をさがす
キーワード
rheumatoid arthritis
biological agents
predictors
DAS28
資料タイプ
学術雑誌論文
抄録
Biological agents represent an important advancement in for the treatment of rheumatoid arthritis (RA), but there is a subset of patients who do not improve despite therapy. This study aimed to determine the efficacy of biological agents for RA and to identify clinical factors that are associated with their response. We studied 98 patients with RA who started an initiating biological agent which was selected from infliximab, etanercept, adalimumab and tociliximab at 4 medical institutions. Etanercept was the most frequently used biological agent followed by infliximab although there was a difference in the selection of the biological agents among medical institutions. We found that etanercept achieved the highest treatment response, remission rate and drug survival rate. A high disease activity in the baseline disease activity score-c-reactive protein (CRP) was shown to be a negative predictor of the treatment response, and high patient global assessment was significantly less likely to achieve a good response. At week 4, decreases in 28 swollen joint counts and CRP were useful as predictors for sustaining the efficacy up to week 48. These data demonstrate that assessments of the disease activity at baseline and the early treatment response may be useful in predicting the efficacy and drug survival rate of biological agents.
掲載誌名
The Journal of Medical Investigation
ISSN
13496867
13431420
cat書誌ID
AA11166929
AA12022913
出版者
Faculty of Medicine Tokushima University
60
1-2
開始ページ
77
終了ページ
90
並び順
77
発行日
2013-02
EDB ID
出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
出版社版
部局
医学系
病院