ID | 110102 |
タイトル別表記 | 高い変形能を示すチタン繊維編物内部への骨成長
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著者 |
邉見, 蓉子
徳島大学大学院口腔科学教育部(口腔科学専攻)
Jimbo, Ryo
Malmö University
Jinno, Yohei
Malmö University
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キーワード | biocompatible materials
bone formation
bone substitutes
elastic modulus
histological techniques
titanium
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資料タイプ |
学位論文
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抄録 | Objectives: The objective of this study is to develop a Ti fibre knit block without sintering, and to evaluate its deformability and new bone formation in vivo.
Material and Methods: A Ti fibre with a diameter of 150 μm was knitted to fabricate a Ti mesh tube. The mesh tube was compressed in a metal mould to fabricate porous Ti fibre knit blocks with three different porosities of 88%, 69%, and 50%. The elastic modulus and deformability were evaluated using a compression test. The knit block was implanted into bone defects of a rabbit’s hind limb, and new bone formation was evaluated using micro computed tomography (micro-CT) analysis and histological analysis. Results: The knit blocks with 88% porosity showed excellent deformability, indicating potential appropriateness for bone defect filling. Although the porosities of the knit block were different, they indicated similar elastic modulus smaller than 1 GPa. The elastic modulus after deformation increased linearly as the applied compression stress increased. The micro-CT analysis indicated that in the block with 50% porosity new bone filled nearly all of the pore volume four weeks after implantation. In contrast, in the block with 88% porosity, new bone filled less than half of the pore volume even 12 weeks after implantation. The histological analysis also indicated new bone formation in the block. Conclusions: The titanium fibre knit block with high porosity is potentially appropriate for bone defect filling, indicating good bone ingrowth after porosity reduction with applied compression. |
掲載誌名 |
Journal of Oral & Maxillofacial Research
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ISSN | 2029283X
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出版者 | Journal of Oral & Maxillofacial Research
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巻 | 7
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号 | 4
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開始ページ | e2
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発行日 | 2016-12-28
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備考 | 内容要旨・審査要旨・論文本文の公開:
内容要旨:LID201704261011.pdf 審査要旨:LID201704261012.pdf 論文本文:LID201704261013.pdf 本論文は,著者Yoko Henmiの学位論文として提出され,学位審査・授与の対象となっている。 |
権利情報 | Copyright © Henmi Y, Naito Y, Jimbo R, Jinno Y, Sekine K, Hamada K. Published in the JOURNAL OF ORAL & MAXILLOFACIAL RESEARCH (http://www.ejomr.org), 28 December 2016.
This is an open-access article, first published in the JOURNAL OF ORAL & MAXILLOFACIAL RESEARCH, distributed under the terms of the Creative Commons Attribution-Noncommercial-No Derivative Works 3.0 Unported License(https://creativecommons.org/licenses/by-nc-nd/3.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work and is properly cited. The copyright, license information and link to the original publication on (http://www.ejomr.org) must be included. |
EDB ID | |
出版社版DOI | |
出版社版URL | |
フルテキストファイル | |
言語 |
eng
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著者版フラグ |
博士論文全文を含む
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文科省報告番号 | 甲第3081号
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学位記番号 | 甲口第424号
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学位授与年月日 | 2017-03-23
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学位名 |
博士(歯学)
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学位授与機関 |
徳島大学
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部局 |
病院
歯学系
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