ID 110159
Author
Uddin, Muhammad Myn Division of Experimental Immunology, Institute of Advanced Medical Sciences, University of Tokushima
Ohigashi, Izumi Division of Experimental Immunology, Institute of Advanced Medical Sciences, University of Tokushima Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Motosugi, Ryo Laboratory of Protein Metabolism, Graduate School of Pharmaceutical Sciences, University of Tokyo
Nakayama, Tomomi Laboratory of Protein Metabolism, Graduate School of Pharmaceutical Sciences, University of Tokyo
Sakata, Mie Division of Experimental Immunology, Institute of Advanced Medical Sciences, University of Tokushima
Hamazaki, Jun Laboratory of Protein Metabolism, Graduate School of Pharmaceutical Sciences, University of Tokyo
Nishito, Yasumasa Core Technology and Research Center, Tokyo Metropolitan Institute of Medical Science
Rode, Immanuel Division of Cellular Immunology, German Cancer Research Center
Tanaka, Keiji Laboratory of Protein Metabolism, Tokyo Metropolitan Institute of Medical Science
Takemoto, Tatsuya Laboratory for Embryology, Institute of Advanced Medical Sciences, University of Tokushima Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Murata, Shigeo Laboratory of Protein Metabolism, Graduate School of Pharmaceutical Sciences, University of Tokyo
Takahama, Yousuke Division of Experimental Immunology, Institute of Advanced Medical Sciences, University of Tokushima Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Content Type
Journal Article
Description
The thymus is an organ that produces functionally competent T cells that protect us from pathogens and malignancies. Foxn1 is a transcription factor that is essential for thymus organogenesis; however, the direct target for Foxn1 to actuate thymic T-cell production is unknown. Here we show that a Foxn1-binding cis-regulatory element promotes the transcription of b5t, which has an essential role in cortical thymic epithelial cells to induce positive selection of functionally competent CD8 þ T cells. A point mutation in this genome element results in a defect in b5t expression and CD8 þ T-cell production in mice. The results reveal a Foxn1-b5t transcriptional axis that governs CD8 þ T-cell production in the thymus.
Journal Title
Nature Communications
ISSN
20411723
NCID
AA12645905
Volume
8
Start Page
14419
Published Date
2017-02-08
Remark
Supplementary Information : ncomms_8_14419_s1.pdf
Peer Review File : ncomms_8_14419_s2.pdf
Rights
©The Author(s) 2017 This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
EDB ID
DOI (Published Version)
URL ( Publisher's Version )
FullText File
language
eng
TextVersion
Publisher
departments
Institute of Advanced Medical Sciences