ID 111969
Author
Omoto, Katsuhiro Tokushima University
Maruhama, Kotaro Okayama University
Terayama, Ryuji Okayama University
Yamamoto, Yumiko Okayama University
Matsushita, Osamu Okayama University
Sugimoto, Tomosada Okayama University
Oguma, Keiji
Keywords
botulinum toxin
mechanical allodynia
dorsal root ganglion
transmitter release
Content Type
Journal Article
Description
Despite the absence of synaptic contacts, cross-excitation of neurons in sensory ganglia during signal transmission is considered to be chemically mediated and appears increased in chronic pain states. In this study, we modulated neurotransmitter release in sensory neurons by direct application of type A botulinum neurotoxin (BoNT/A) to sensory ganglia in an animal model of neuropathic pain and evaluated the effect of this treatment on nocifensive. Unilateral sciatic nerve entrapment (SNE) reduced the ipsilateral hindpaw withdrawal threshold to mechanical stimulation and reduced hindpaw withdrawal latency to thermal stimulation. Direct application of BoNT/A to the ipsilateral L4 dorsal root ganglion (DRG) was localized in the cell bodies of the DRG and reversed the SNE-induced decreases in withdrawal thresholds within 2 days of BoNT/A administration. Results from this study suggest that neurotransmitter release within sensory ganglia is involved in the regulation of pain-related signal transmission.
Journal Title
Toxins
ISSN
20726651
Publisher
MDPI
Volume
7
Issue
8
Start Page
2906
End Page
2917
Published Date
2015-08-04
Rights
© 2015 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article
distributed under the terms and conditions of the Creative Commons Attribution license(http://creativecommons.org/licenses/by/4.0/).
EDB ID
DOI (Published Version)
URL ( Publisher's Version )
FullText File
language
eng
TextVersion
Publisher
departments
Oral Sciences