ID 112969
Author
Taniguchi, Yuka The University of Tokushima
Tachibana, Ayaka The University of Tokushima
Yano, Yuya The University of Tokushima
Yano, Kiyohito The University of Tokushima
Yamasaki, Mikio The University of Tokushima KAKEN Search Researchers
Hinokio, Kenji The University of Tokushima
Keywords
assisted reproductive technology
estradiol
follicular fluid
kisspeptin
mature oocyte
Content Type
Journal Article
Description
Purpose: To assess the kisspeptin concentrations in follicular fluid and their relationship with clinical outcomes during assisted reproductive technology.
Methods: Thirty-nine patients who were aged 24-40 years and underwent oocyte retrieval for in vitro fertilization/intracytoplasmic sperm injection participated in this study. In 65 follicular fluid samples that had been obtained from 30 patients and their blood samples, the kisspeptin levels were measured in order to investigate the correlations with their gonadal hormone levels. Venous blood samples were collected from 14 patients to investigate their plasma kisspeptin levels across different phases of assisted reproductive technology.
Results: The follicular fluid kisspeptin level was significantly higher than that of the plasma level and was positively associated with the follicular fluid estradiol concentration and with the serum estradiol and number of mature oocytes. In the plasma, the maximum concentration of kisspeptin was observed on the day of ovum pick-up and on the day of embryo transfer during ovarian stimulation for assisted reproductive technology.
Conclusion: Kisspeptin was present in the follicular fluid and the plasma kisspeptin concentration was affected by ovarian stimulation. Kisspeptin appears to affect oocyte maturation and ovulation.
Journal Title
Reproductive Medicine and Biology
ISSN
14470578
NCID
AA11706516
Publisher
Japan Society for Reproductive Medicine|John Wiley & Sons Australia, Ltd
Volume
16
Issue
4
Start Page
380
End Page
385
Published Date
2017-09-16
Rights
© 2017 The Authors. Reproductive Medicine and Biology published by John Wiley & Sons Australia, Ltd on behalf of Japan Society for Reproductive Medicine. This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/), which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
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DOI (Published Version)
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language
eng
TextVersion
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departments
University Hospital
Medical Sciences