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ID 116926
Author
Bando, Hiroshi Tokushima University|Japan Low Carbohydrate Diet Promotion Association|Sakamoto Hospital KAKEN Search Researchers
Okada, M Sakamoto Hospital
Iwatsuki, N Sakamoto Hospital
Sakamoto, K Sakamoto Hospital
Ogawa, T Sakamoto Hospital
Keywords
Oral Hypoglycemic Agent (OHA)
Imeglimin
Twymeeg
Glucose-Stimulated Insulin Secretion (GSIS)
Type 2 Diabetes Mellitus (T2DM)
Content Type
Journal Article
Description
Background: As a novel oral hypoglycemic agent (OHA), imeglimin has been recently applied for patients with type 2 diabetes mellitus (T2DM) as Twymeeg. It has beneficial twin mechanisms associated with increasing insulin secretion, and decreasing insulin resistance. It has a triazine ring and become the first OHA for tetrahydrotriazine-containing agent in the category of the glimins.
Case presentation: The case is 84-year-old female with T2DM and mild cognitive impairment (MCI). Her HbA1c was 9.3% a year ago.
Results: She was begun to receive Dulaglutide 0.75mg/week and showed 1.3% HbA1c reduction for 6 months. However, HbA1c was elevated again to 8.5%, and then she was provided Twymeeg 2000mg/day. HbA1c decreased from 8.5% to 7.5% in 3 months. [Discussion and conclusion] From combined treatments of imeglimin and other agents in the previous study, mean HbA1c reduction showed single imiglimin -0.46%, DPP-4i -0.92% and GLP-1RA -0.12%. Possible reason for the difference between the latter two suggests that multiple action mechanisms of imeglimin may be present including the enhancement of glucose-stimulated insulin secretion (GSIS). In contrast, she showed satisfactory HbA1c reduction by the combination of imeglimin and GLP-1RA. The pathophysiology is not clear, and future follow up the clinical progress will be required.
Journal Title
International Journal of Endocrinology and Diabetes
ISSN
26943875
Publisher
Pubtexto Publishers
Volume
5
Issue
1
Start Page
135
Published Date
2022-02-28
Rights
This is an open-access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
DOI (Published Version)
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language
eng
TextVersion
Publisher
departments
Medical Sciences