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ID 116413
Author
Bando, Hiroshi Tokushima University|Integrative Medicine Japan|Japan Low Carbohydrate Diet Promotion Association KAKEN Search Researchers
Keywords
Glucagon-Like Peptide 1 (GLP-1)
GLP-1 receptor agonist (GLP-1RA)
blood brain barrier (BBB)
Semaglutide
weight reduction
Content Type
Journal Article
Description
For humans, eating control is crucial. When metabolic homeostasis can be maintained, feeding function involves the hypothalamus and brain stem. When food intake exceeds metabolic homeostasis, reward system is involved such as dopamine neurons from the ventral tegmental area, the nucleus accumbens, and limbic system and to the neocortex. Physiological effects of Glucagon-Like Peptide 1 (GLP-1) include improving glucose metabolism, delaying gastric emptying, and suppressing appetite. GLP-1 receptor agonist (GLP-1RA) is supposed to cross the blood brain barrier (BBB) and act on the central nervous system (CNS), associated with weight reduction effect, delaying gastric emptying via the vagus nerve system.
Journal Title
Recent Research in Endocrinology and Metabolic Disorder
ISSN
27175138
Volume
3
Issue
1
Start Page
40
End Page
43
Published Date
2021-10-25
Rights
This open access article is licensed under Creative Commons Attribution 4.0 International (CC BY 4.0). http://creativecommons.org/licenses/by/4.0
DOI (Published Version)
URL ( Publisher's Version )
FullText File
language
eng
TextVersion
Publisher
departments
Medical Sciences