| ID | 116413 |
| Author |
Bando, Hiroshi
Tokushima University|Integrative Medicine Japan|Japan Low Carbohydrate Diet Promotion Association
KAKEN Search Researchers
|
| Keywords | Glucagon-Like Peptide 1 (GLP-1)
GLP-1 receptor agonist (GLP-1RA)
blood brain barrier (BBB)
Semaglutide
weight reduction
|
| Content Type |
Journal Article
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| Description | For humans, eating control is crucial. When metabolic homeostasis can be maintained, feeding function involves the hypothalamus and brain stem. When food intake exceeds metabolic homeostasis, reward system is involved such as dopamine neurons from the ventral tegmental area, the nucleus accumbens, and limbic system and to the neocortex. Physiological effects of Glucagon-Like Peptide 1 (GLP-1) include improving glucose metabolism, delaying gastric emptying, and suppressing appetite. GLP-1 receptor agonist (GLP-1RA) is supposed to cross the blood brain barrier (BBB) and act on the central nervous system (CNS), associated with weight reduction effect, delaying gastric emptying via the vagus nerve system.
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| Journal Title |
Recent Research in Endocrinology and Metabolic Disorder
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| ISSN | 27175138
|
| Volume | 3
|
| Issue | 1
|
| Start Page | 40
|
| End Page | 43
|
| Published Date | 2021-10-25
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| Rights | This open access article is licensed under Creative Commons Attribution 4.0 International (CC BY 4.0). http://creativecommons.org/licenses/by/4.0
|
| FullText File | |
| language |
eng
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| TextVersion |
Publisher
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| departments |
Medical Sciences
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