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  2. Otaka, Akira

Otaka, Akira

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Development of a Reduction‐Responsive Amino Acid that Induces Peptide Bond Cleavage in Hypoxic Cells
Author Shigenaga, Akira/ Ogura, Keiji/ Hirakawa, Hiroko/ Yamamoto, Jun/ Ebisuno, Koji/ Miyamoto, Licht/ Ishizawa, Keisuke/ Tsuchiya, Koichiro/ Otaka, Akira/
Content Type Journal Article
Journal Title ChemBioChem
Volume 13
Issue 7
Published Date 2012-04-13
departments Pharmaceutical Sciences Medical Sciences
Facile synthesis of C-terminal peptide thioacids under mild conditions from N-sulfanylethylanilide peptides
Author Shimizu, Tatsuhiko/ Miyajima, Rin/ Sato, Kohei/ Sakamoto, Ken/ Naruse, Naoto/ Kita, Miku/ Shigenaga, Akira/ Otaka, Akira/
Content Type Journal Article
Journal Title Tetrahedron
Volume 72
Issue 7
Published Date 2015-12-29
departments Pharmaceutical Sciences
Facile Preparation of Peptides with C-Terminal N-Alkylamide via Radical-Initiated Dethiocarboxylation
Author Shimizu, Tatsuhiko/ Miyajima, Rin/ Naruse, Naoto/ Yamaoka, Kosuke/ Aihara, Keisuke/ Shigenaga, Akira/ Otaka, Akira/
Content Type Journal Article
Journal Title Chemical and Pharmaceutical Bulletin
Volume 64
Issue 4
Published Date 2016-04-01
departments Pharmaceutical Sciences
ProteoFind : A script for finding proteins that are suitable for chemical synthesis
Author Shigenaga, Akira/ Naruse, Naoto/ Otaka, Akira/
Content Type Journal Article
Journal Title Tetrahedron
Volume 74
Issue 19
Published Date 2018-03-15
departments Pharmaceutical Sciences
Chemical Synthetic Platform for Chlorpromazine Oligomers That Were Reported as Photo-degradation Products of Chlorpromazine
Author Kohiki, Taiki/ Nishikawa, Yusuke/ Inokuma, Tsubasa/ Shigenaga, Akira/ Otaka, Akira/
Content Type Journal Article
Journal Title Chemical and Pharmaceutical Bulletin
Volume 65
Issue 12
Published Date 2017-12-01
departments Pharmaceutical Sciences
Invention of stimulus‐responsive peptide‐bond‐cleaving residue (Spr) and its application to chemical biology tools
Author Shigenaga, Akira/ Yamamoto, Jun/ Kohiki, Taiki/ Inokuma, Tsubasa/ Otaka, Akira/
Content Type Journal Article
Journal Title Journal of Peptide Science
Volume 23
Issue 7-8
Published Date 2017-01-19
departments Pharmaceutical Sciences
刺激応答型アミノ酸の開発と生命科学分野への展開
Author Shigenaga, Akira/ Otaka, Akira/
Content Type Journal Article
Journal Title Chemical Industry
Volume 65
Issue 11
Published Date 2014-11
departments Pharmaceutical Sciences
Effect of Phosphatidylserine and Cholesterol on Membrane-mediated Fibril Formation by the N-terminal Amyloidogenic Fragment of Apolipoprotein A-I
Author Mizuguchi, Chiharu/ Nakamura, Mitsuki/ Kurimitsu, Naoko/ Ohgita, Takashi/ Nishitsuji, Kazuchika/ Baba, Teruhiko/ Shigenaga, Akira/ Shimanouchi, Toshinori/ Okuhira, Keiichiro/ Otaka, Akira/ Saito, Hiroyuki/
Content Type Journal Article
Journal Title Scientific Reports
Volume 8
Published Date 2018-04-03
departments Medical Sciences Pharmaceutical Sciences
Light-induced propulsion of a giant liposome driven by peptide nanofibre growth
Author Inaba, Hiroshi/ Uemura, Akihito/ Morishita, Kazushi/ Kohiki, Taiki/ Shigenaga, Akira/ Otaka, Akira/ Matsuura, Kazunori/
Content Type Journal Article
Journal Title Scientific Reports
Volume 8
Published Date 2018-04-19
departments Pharmaceutical Sciences
Traceless synthesis of protein thioesters using enzyme-mediated hydrazinolysis and subsequent self-editing of cysteinyl prolyl sequence
Author Komiya, Chiaki/ Shigenaga, Akira/ Tsukimoto, Jun/ Ueda, Masahiro/ Morisaki, Takuya/ Inokuma, Tsubasa/ Itoh, Kohji/ Otaka, Akira/
Content Type Journal Article
Journal Title Chemical Communications
Volume 55
Issue 49
Published Date 2019-05-23
departments Pharmaceutical Sciences
CXCL14 Acts as a Specific Carrier of CpG DNA into Dendritic Cells and Activates Toll-like Receptor 9-mediated Adaptive Immunity
Author Tanegashima, Kosuke/ Takahashi, Rena/ Nuriya, Hideko/ Iwase, Rina/ Naruse, Naoto/ Tsuji, Kohei/ Shigenaga, Akira/ Otaka, Akira/ Hara, Takahiko/
Content Type Journal Article
Journal Title EBioMedicine
Volume 24
Published Date 2017-09-14
departments Pharmaceutical Sciences
Asymmetric Synthesis of α‐Amino Phosphonic Acids using Stable Imino Phosphonate as a Universal Precursor
Author Inokuma, Tsubasa/ Sakakibara, Takuya/ Someno, Takatoshi/ Masui, Kana/ Shigenaga, Akira/ Otaka, Akira/ Yamada, Ken-ichi/
Content Type Journal Article
Journal Title Chemistry- A European Journal
Volume 25
Issue 60
Published Date 2019-08-26
departments Pharmaceutical Sciences
Development of a Chemical Methodology for the Preparation of Peptide Thioesters Applicable to Naturally Occurring Peptides Using a Sequential Quadruple Acyl Transfer System
Author Tsuda, Yusuke/ Shigenaga, Akira/ Tsuji, Kohei/ Denda, Masaya/ Sato, Kohei/ Kitakaze, Keisuke/ Nakamura, Takahiro/ Inokuma, Tsubasa/ Itoh, Kohji/ Otaka, Akira/
Content Type Journal Article
Journal Title ChemistryOpen
Volume 4
Issue 4
Published Date 2015-04-28
departments Pharmaceutical Sciences
Labelling of Endogenous Target Protein via N–S Acyl Transfer-Mediated Activation of N-Sulfanylethylanilide
Author Denda, Masaya/ Morisaki, Takuya/ Kohiki, Taiki/ Yamamoto, Jun/ Sato, Kohei/ Sagawa, Ikuko/ Inokuma, Tsubasa/ Sato, Youichi/ Yamauchi, Aiko/ Shigenaga, Akira/ Otaka, Akira/
Content Type Journal Article
Journal Title Organic & Biomolecular Chemistry
Volume 14
Issue 26
Published Date 2016-05-31
departments Technical Support Department Pharmaceutical Sciences
Development of a fluoride-responsive amide bond cleavage device that is potentially applicable to a traceable linker
Author Yamamoto, Jun/ Maeda, Nami/ Komiya, Chiaki/ Tanaka, Tomohiro/ Denda, Masaya/ Ebisuno, Koji/ Nomura, Wataru/ Tamamura, Hirokazu/ Sato, Youichi/ Yamauchi, Aiko/ Shigenaga, Akira/ Otaka, Akira/
Content Type Journal Article
Journal Title Tetrahedron
Volume 70
Issue 34
Published Date 2014-06-06
departments Pharmaceutical Sciences
Development of caged non-hydrolyzable phosphoamino acids and application to photo-control of binding affinity of phosphopeptide mimetic to phosphopeptide-recognizing protein
Author Ebisuno, Koji/ Denda, Masaya/ Ogura, Keiji/ Inokuma, Tsubasa/ Shigenaga, Akira/ Otaka, Akira/
Content Type Journal Article
Journal Title Bioorganic & Medicinal Chemistry
Volume 22
Issue 11
Published Date 2014-04-13
departments Pharmaceutical Sciences
Development of a traceable linker containing a thiol-responsive amino acid for the enrichment and selective labelling of target proteins
Author Yamamoto, Jun/ Denda, Masaya/ Maeda, Nami/ Kita, Miku/ Komiya, Chiaki/ Tanaka, Tomohiro/ Nomura, Wataru/ Tamamura, Hirokazu/ Sato, Youichi/ Yamauchi, Aiko/ Shigenaga, Akira/ Otaka, Akira/
Content Type Journal Article
Journal Title Organic & Biomolecular Chemistry
Volume 12
Issue 23
Published Date 2014-04-17
departments Pharmaceutical Sciences
An N-sulfanylethylanilide-based traceable linker for enrichment and selective labelling of target proteins
Author Morisaki, Takuya/ Denda, Masaya/ Yamamoto, Jun/ Tsuji, Daisuke/ Inokuma, Tsubasa/ Itoh, Kohji/ Shigenaga, Akira/ Otaka, Akira/
Content Type Journal Article
Journal Title Chemical Communications
Volume 52
Issue 42
Published Date 2016-04-26
departments Pharmaceutical Sciences
Elucidation of inhibitor-binding pockets of D-amino acid oxidase using docking simulation and N-sulfanylethylanilide-based labeling technology
Author Kohiki, Taiki/ Kato, Yusuke/ Nishikawa, Yusuke/ Yorita, Kazuko/ Sagawa, Ikuko/ Denda, Masaya/ Inokuma, Tsubasa/ Shigenaga, Akira/ Fukui, Kiyoshi/ Otaka, Akira/
Content Type Journal Article
Journal Title Organic & Biomolecular Chemistry
Volume 15
Issue 25
Published Date 2017-05-05
departments Institute of Advanced Medical Sciences Technical Support Department Pharmaceutical Sciences
Sulfanylmethyldimethylaminopyridine as a Useful Thiol Additive for Ligation Chemistry in Peptide/Protein Synthesis
Author Ohkawachi, Kento/ Kobayashi, Daishiro/ Morimoto, Kyohei/ Shigenaga, Akira/ Denda, Masaya/ Yamatsugu, Kenzo/ Kanai, Motomu/ Otaka, Akira/
Content Type Journal Article
Journal Title Organic Letters
Volume 22
Issue 14
Published Date 2020-05-12
departments Pharmaceutical Sciences
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