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  2. Otaka, Akira

Otaka, Akira

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Stapled BIG3 helical peptide ERAP potentiates anti-tumour activity for breast cancer therapeutics
Author Yoshimaru, Tetsuro/ Aihara, Keisuke/ Komatsu, Masato/ Matsushita, Yosuke/ Okazaki, Yasumasa/ Toyokuni, Shinya/ Honda, Junko/ Sasa, Mitsunori/ Miyoshi, Yasuo/ Otaka, Akira/ Katagiri, Toyomasa/
Content Type Journal Article
Journal Title Scientific Reports
Volume 7
Published Date 2017-05-12
departments Institute of Advanced Medical Sciences Pharmaceutical Sciences
Development of a 1,3a,6a-triazapentalene derivative as a compact and thiol-specific fluorescent labeling reagent
Author Nakayama, Atsushi/ Otani, Akira/ Inokuma, Tsubasa/ Tsuji, Daisuke/ Mukaiyama, Haruka/ Nakayama, Akira/ Itoh, Kohji/ Otaka, Akira/ Tanino, Keiji/ Namba, Kosuke/
Content Type Journal Article
Journal Title Communications Chemistry
Volume 3
Published Date 2020-01-09
departments Pharmaceutical Sciences
Development of an Anilide-Type Scaffold for the Thioester Precursor N-Sulfanylethylcoumarinyl Amide
Author Eto, Mitsuhiro/ Naruse, Naoto/ Morimoto, Kyohei/ Yamaoka, Kosuke/ Sato, Kohei/ Tsuji, Kohei/ Inokuma, Tsubasa/ Shigenaga, Akira/ Otaka, Akira/
Content Type Journal Article
Journal Title Organic Letters
Volume 18
Issue 17
Published Date 2016-08-16
departments Pharmaceutical Sciences
Tailored Synthesis of 162-Residue S-Monoglycosylated GM2-Activator Protein (GM2AP) Analogues that Allows Facile Access to Protein Library
Author Nakamura, Takahiro/ Sato, Kohei/ Naruse, Naoto/ Kitakaze, Keisuke/ Inokuma, Tsubasa/ Hirokawa, Takatsugu/ Shigenaga, Akira/ Itoh, Kohji/ Otaka, Akira/
Content Type Journal Article
Journal Title ChemBioChem
Volume 17
Issue 20
Published Date 2016-08-19
departments Pharmaceutical Sciences
The total chemical synthesis of the monoglycosylated GM2 ganglioside activator using a novel cysteine surrogate
Author Sato, Kohei/ Kitakaze, Keisuke/ Nakamura, Takahiro/ Naruse, Naoto/ Aihara, Keisuke/ Shigenaga, Akira/ Inokuma, Tsubasa/ Tsuji, Daisuke/ Itoh, Kohji/ Otaka, Akira/
Content Type Journal Article
Journal Title Chemical Communications
Volume 51
Issue 49
Published Date 2015-05-13
departments Pharmaceutical Sciences
Synthesis of lactam-bridged cyclic peptides using sequential olefin metathesis and diimide reduction reactions
Author Aihara, Keisuke/ Inokuma, Tsubasa/ Komiya, Chiaki/ Shigenaga, Akira/ Otaka, Akira/
Content Type Journal Article
Journal Title Tetrahedron
Volume 71
Issue 24
Published Date 2015-05-01
departments Pharmaceutical Sciences
Cysteine-Free Intramolecular Ligation of N-Sulfanylethylanilide Peptide Using 4-Mercaptobenzylphosphonic Acid : Synthesis of Cyclic Peptide Trichamide
Author Aihara, Keisuke/ Inokuma, Tsubasa/ Jichu, Takahisa/ Lin, Zhenjian/ Fu, Feixue/ Yamaoka, Kosuke/ Shigenaga, Akira/ Hutchins, David A./ Schmidt, Eric W./ Otaka, Akira/
Content Type Journal Article
Journal Title Synlett
Volume 28
Issue 15
Published Date 2017-07-06
departments Pharmaceutical Sciences
Resin-Bound Crypto-Thioester for Native Chemical Ligation
Author Naruse, Naoto/ Ohkawachi, Kento/ Inokuma, Tsubasa/ Shigenaga, Akira/ Otaka, Akira/
Content Type Journal Article
Journal Title Organic Letters
Volume 20
Issue 8
Published Date 2018-04-09
departments Pharmaceutical Sciences
Liquid-Phase Synthesis of Bridged Peptides Using Olefin Metathesis of a Protected Peptide with a Long Aliphatic Chain Anchor
Author Aihara, Keisuke/ Komiya, Chiaki/ Shigenaga, Akira/ Inokuma, Tsubasa/ Takahashi, Daisuke/ Otaka, Akira/
Content Type Journal Article
Journal Title Organic Letters
Volume 17
Issue 3
Published Date 2015-01-28
departments Pharmaceutical Sciences
A recyclable hydrophobic anchor-tagged asymmetric amino thiourea catalyst
Author Jichu, Takahisa/ Inokuma, Tsubasa/ Aihara, Keisuke/ Kohiki, Taiki/ Nishida, Kodai/ Shigenaga, Akira/ Yamada, Ken-ichi/ Otaka, Akira/
Content Type Journal Article
Journal Title ChemCatChem
Volume 10
Issue 16
Published Date 2018-07-11
departments Pharmaceutical Sciences
Development of an intein-inspired amide cleavage chemical device
Author Komiya, Chiaki/ Aihara, Keisuke/ Morishita, Ko/ Ding, Hao/ Inokuma, Tsubasa/ Shigenaga, Akira/ Otaka, Akira/
Content Type Journal Article
Journal Title The Journal of Organic Chemistry
Volume 81
Issue 2
Published Date 2015-12-08
departments Pharmaceutical Sciences
Preparation of Peptide Thioesters from Naturally Occurring Sequences Using Reaction Sequence Consisting of Regioselective S-Cyanylation and Hydrazinolysis
Author Miyajima, Rin/ Tsuda, Yusuke/ Inokuma, Tsubasa/ Shigenaga, Akira/ Imanishi, Miki/ Futaki, Shiroh/ Otaka, Akira/
Content Type Journal Article
Journal Title Biopolymers(Peptide Science)
Volume 106
Issue 4
Published Date 2015-10-26
departments Pharmaceutical Sciences
Synthesis of a Stimulus-responsive Processing Device and Its Application to a Nucleocytoplasmic Shuttle Peptide
Author Shigenaga, Akira/ Tsuji, Daisuke/ Nishioka, Naomi/ Tsuda, Shugo/ Itoh, Kohji/ Otaka, Akira/
Content Type Journal Article
Journal Title ChemBioChem
Volume 8
Issue 16
Published Date 2007-09-26
departments Pharmaceutical Sciences
Development of thiol-responsive amide bond cleavage device and its application for peptide nucleic acid-based DNA releasing system
Author Shigenaga, Akira/ Yamamoto, Jun/ Hirakawa, Hiroko/ Ogura, Keiji/ Maeda, Nami/ Morishita, Ko/ Otaka, Akira/
Content Type Journal Article
Journal Title Tetrahedron Letters
Volume 51
Issue 18
Published Date 2010-03-03
departments Pharmaceutical Sciences
FRET-based assay of the processing reaction kinetics of stimulus-responsive peptides : influence of amino acid sequence on reaction kinetics
Author Shigenaga, Akira/ Yamamoto, Jun/ Hirakawa, Hiroko/ Yamaguchi, Keiko/ Otaka, Akira/
Content Type Journal Article
Journal Title Tetrahedron
Volume 65
Issue 11
Published Date 2009-01-20
departments Pharmaceutical Sciences
Development and photo-responsive peptide bond cleavage reaction of two-photon near-infrared excitation-responsive peptide
Author Shigenaga, Akira/ Yamamoto, Jun/ Sumikawa, Yoshitake/ Furuta, Toshiaki/ Otaka, Akira/
Content Type Journal Article
Journal Title Tetrahedron Letters
Volume 51
Issue 21
Published Date 2010-03-23
departments Pharmaceutical Sciences
Enantioselective synthesis of stimulus-responsive amino acid via asymmetric α-amination of aldehyde
Author Shigenaga, Akira/ Yamamoto, Jun/ Nishioka, Naomi/ Otaka, Akira/
Content Type Journal Article
Journal Title Tetrahedron
Volume 66
Issue 37
Published Date 2010-07-21
departments Pharmaceutical Sciences
Development of UV-responsive catch-and-release system of a cysteine protease model peptide
Author Shigenaga, Akira/ Morishita, Ko/ Yamaguchi, Keiko/ Ding, Hao/ Ebisuno, Koji/ Sato, Kohei/ Yamamoto, Jun/ Akaji, Kenichi/ Otaka, Akira/
Content Type Journal Article
Journal Title Tetrahedron
Volume 67
Issue 46
Published Date 2011-09-21
departments Pharmaceutical Sciences
Design and synthesis of caged ceramide : UV-responsive ceramide releasing system based on UV-induced amide bond cleavage followed by O–N acyl transfer
Author Shigenaga, Akira/ Hirakawa, Hiroko/ Yamamoto, Jun/ Ogura, Keiji/ Denda, Masaya/ Yamaguchi, Keiko/ Tsuji, Daisuke/ Itoh, Kohji/ Otaka, Akira/
Content Type Journal Article
Journal Title Tetrahedron
Volume 67
Issue 22
Published Date 2011-04-20
departments Pharmaceutical Sciences
Design and synthesis of a hydrogen peroxide-responsive amino acid that induces peptide bond cleavage after exposure to hydrogen peroxide
Author Kita, Miku/ Yamamoto, Jun/ Morisaki, Takuya/ Komiya, Chiaki/ Inokuma, Tsubasa/ Miyamoto, Licht/ Tsuchiya, Koichiro/ Shigenaga, Akira/ Otaka, Akira/
Content Type Journal Article
Journal Title Tetrahedron Letters
Volume 56
Issue 28
Published Date 2015-05-21
departments Pharmaceutical Sciences
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