ID 111273
Title Alternative
過剰なリン摂取は若年健常男性において血管内皮機能を障害する : 時間・用量試験
Author
Nishi, Tamae University of Tokushima|Kurashiki Medical Center
Ogawa, Mariko University of Tokushima
Ohya, Miho University of Tokushima
Nakanishi, Misaki University of Tokushima
Katsumoto, Misaki University of Tokushima
Keywords
phosphorus
endothelial dysfunction
flow-mediated vasodilation
hyperphosphatemia
chronic kidney disease
Content Type
Thesis or Dissertation
Description
Excessive dietary phosphorus (P) has been speculated to be a risk factor for cardiovascular disease (CVD). Here, we performed a double-blinded crossover study to investigate the time- and dose-dependent effects of dietary P intake on endothelial function in healthy subjects. Sixteen healthy male volunteers were given meals containing 400, 800, and 1,200 mg P (P400, P800, and P1200 meals, respectively) with at least 7 days between doses. There were no differences in nutritional composition among the experimental diets except for P content. Blood biochemistry data and flow-mediated dilation (%FMD) of the brachial artery were measured while fasted, at 0 h, 1 h, 2 h, and 4 h after meal ingestion, and the next morning while fasted. The P800 and P1200 meals significantly increased serum P levels at 1-4 h after ingestion. A significant decrease in %FMD was observed between 1-4 h, while the P400 meal did not affect %FMD. We observed no differences among meals in serum P levels or %FMD the next morning. A significant negative correlation was observed between %FMD and serum P. These results indicate that excessive dietary P intake can acutely impair endothelial function in healthy people.
Journal Title
The Journal of Medical Investigation
ISSN
13496867
13431420
NCID
AA11166929
AA12022913
Publisher
Faculty of Medicine Tokushima University
Volume
62
Issue
3-4
Start Page
167
End Page
172
Sort Key
167
Published Date
2015-08
Remark
内容要旨・審査要旨・論文本文の公開:
内容要旨・審査要旨 : LID201506051001.pdf
論文本文 : LID201509141001.pdf
本論文は,著者Tamae Nishiの学位論文として提出され,学位審査・授与の対象となっている。
EDB ID
DOI (Published Version)
URL ( Publisher's Version )
FullText File
language
eng
TextVersion
ETD
MEXT report number
甲第2847号
Diploma Number
甲栄第225号
Granted Date
2015-03-23
Degree Name
Doctor of Nutritional Science
Grantor
Tokushima University
departments
Medical Sciences