ID 113364
Title Alternative
グレリンの脳室内投与はラットにおいて回転カゴ運動を減少させる
Author
Miyatake, Yumiko Tokushima University
Toda, Satomi Tokushima University
Taniguchi, Yasuko Tokushima University
Futami, Akari Tokushima University
Sato, Fukiko Tokushima University
Sebe, Mayu Tokushima University
Minokoshi, Yasuhiko National Institute for Physiological Sciences
Kitamura, Tadahiro Gunma University
Gotoh, Koro Oita University
Ueno, Masaki Kagawa University
Keywords
Ghrelin
Voluntary exercise
Central nervous system
SPORTS rat
Content Type
Thesis or Dissertation
Description
There is an increasing interest in elucidating the molecular mechanisms by which voluntary exercise is regulated. In this study, we examined how the central nervous system regulates exercise. We used SPORTS rats, which were established in our laboratory as a highly voluntary murine exercise model. SPORTS rats showed lower levels of serum ghrelin compared with those of the parental line of Wistar rats. Intrac-erebroventricular and intraperitoneal injection of ghrelin decreased wheel-running activity in SPORTS rats. In addition, daily injection of the ghrelin inhibitor JMV3002 into the lateral ventricles of Wistar rats increased wheel-running activity. Co-administration of obestatin inhibited ghrelin-induced increases in food intake but did not inhibit ghrelin-induced suppression of voluntary exercise in rats. Growth hormone secretagogue receptor (GHSR) in the hypothalamus and hippocampus of SPORTS rats was not difference that in control rats. We created an arcuate nucleus destruction model by administering monosodium glutamate (MSG) to neonatal SPORTS rats. Injection of ghrelin into MSG-treated rats decreased voluntary exercise but did not increase food intake, suggesting that wheel-running activity is not controlled by the arcuate nucleus neurons that regulate feeding. These results provide new insights into the mechanism by which ghrelin regulates voluntary activity independent of arcuate nucleus neurons.
Journal Title
Peptides
ISSN
01969781
NCID
AA10617807
AA11536405
Publisher
Elsevier Inc.
Volume
87
Start Page
12
End Page
19
Published Date
2016-11-05
Remark
内容要旨・審査要旨・論文本文の公開
本論文は,著者Yumiko Miyatakeの学位論文として提出され,学位審査・授与の対象となっている。
EDB ID
DOI (Published Version)
URL ( Publisher's Version )
FullText File
language
eng
TextVersion
ETD
MEXT report number
甲第3274号
Diploma Number
甲栄第263号
Granted Date
2019-03-22
Degree Name
Doctor of Nutritional Science
Grantor
Tokushima University
departments
Medical Sciences