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ID 116667
Morioka, Masakazu University of Fukui
Takamura, Yoshihiro University of Fukui
Nagai, Kazuki Gunma University
Yoshida, Shigeo Kurume University
Mori, Junya Sapporo City General Hospital
Takeuchi, Masaru National Defense Medical College
Sawada, Tomoko Shiga University of Medical Science
Sone, Kumiko Tokyo Medical University
Fukuyama, Hisashi Hyogo College of Medicine
Kusuhara, Sentaro Kobe University
Yasukawa, Tsutomu Nagoya City University
Murakami, Tomoya University of Tsukuba
Tabuchi, Hitoshi Saneikai Tsukazaki Hospital
Nagasato, Daisuke Saneikai Tsukazaki Hospital
Hirano, Takao Shinshu University
Ueda, Tetsuo Nara Medical University
Jujo, Tatsuya St. Marianna University
Sasajima, Hirofumi Aichi Medical University
Ishikawa, Kunihiro Tokyo Women’s Medical University
Inatani, Masaru University of Fukui
Content Type
Journal Article
Intravitreal injection (IVI) of anti-vascular endothelial growth factor (VEGF) is the standard treatment modality in various types of retinal diseases. However, endophthalmitis remains the most serious complication. Despite the lack of evidence that antibiotics prevent endophthalmitis, topical antibiotics are still used routinely in Japan. We conducted a retrospective multicenter study by analyzing records from patients who underwent IVI of anti-VEGF agents with or without antibiotic treatment. In the analysis of a total of 147,440 eyes, the incidence of endophthalmitis was 0.007%: 0.005% with no use of antibiotics, 0.009% with antibiotic pretreatment, 0.012% with posttreatment, and 0.005% with pre- and posttreatment. There was no statistically significant difference among the four groups (chi-square test, p = 0.57). Most facilities used masks, sterilized gloves, and drapes. Nine of the 10 eyes that developed endophthalmitis received topical antibiotics, and all infected eyes underwent IVI with aflibercept, not the prefilled syringe delivery system. In four patients who received multiple IVI, the detection of causative bacteria revealed resistance to used antibiotics. Data from this large population, treated with or without antibiotics, suggests that antibiotic prophylaxis does not reduce the rate of endophthalmitis after IVI.
Journal Title
Scientific Reports
Springer Nature
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Medical Sciences