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ID 113579
Title Alternative
Selective Effects of Emi1 Depletion in Cancer
Author
Shimizu, Natsumi Hiroshima University|Kinki University
Izumi Nakajima, Nakako National Institute of Radiological Sciences
Ogawa, Ikuko Hiroshima University
Kawai, Hidehiko Hiroshima University
Hirayama, Ryoichi National Institute of Radiological Sciences
Fujimori, Akira National Institute of Radiological Sciences
Okayasu, Ryuichi National Institute of Radiological Sciences
Takata, Takashi Hiroshima University
Content Type
Journal Article
Description
Background: To improve the effectiveness of chemo- and radiotherapy only in cancer tissue is important for avoiding side effects.
Results: Emi1 depletion enhanced the sensitivity of anticancer reagents and X-ray irradiation in cancer cells.
Conclusion: Emi1 siRNA would be a useful new modality for enhancing the effect of chemo- and radiotherapy in various tumors.
Significance: This work provides new insights regarding synergistic effect of Emi1 knockdown in combination therapies.
Journal Title
Journal of Biological Chemistry
ISSN
1083351X
NCID
AA1202441X
Publisher
The American Society for Biochemistry and Molecular Biology
Volume
288
Issue
24
Start Page
17238
End Page
17252
Published Date
2013-05-03
Remark
This research was originally published in the Journal of Biological Chemistry. Natsumi Shimizu, Nakako Izumi Nakajima, Takaaki Tsunematsu, Ikuko Ogawa, Hidehiko Kawai, Ryoichi Hirayama, Akira Fujimori, Akiko Yamada, Ryuichi Okayasu, Naozumi Ishimaru, Takashi Takata and Yasusei Kudo. Selective Enhancing Effect of Early Mitotic Inhibitor 1 (Emi1) Depletion on the Sensitivity of Doxorubicin or X-ray Treatment in Human Cancer Cells. J. Biol. Chem. 2013; Vol:288(24) pp.17238-17252.
Rights
© 2013 by The American Society for Biochemistry and Molecular Biology, Inc.
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language
eng
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Medical Sciences
Oral Sciences