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ID 106159
Title Alternative
マウスにおいて短期間の食餌性リン制限は回腸fibroblast growth factor 15遺伝子発現量を増加させる
Author
Nakahashi, Otoki University of Tokushima
Yamamoto, Hironori University of Tokushima|Jin-ai University|University of Fukui KAKEN Search Researchers
Tanaka, Sarasa University of Tokushima
Kozai, Mina University of Tokushima
Takei, Yuichiro University of Tokushima
Iwano, Masayuki University of Fukui
Keywords
fibroblast growth factor 15
gene regulation analysis
inorganic phosphate
1,25-dihydroxyvitamin D
mice
Content Type
Thesis or Dissertation
Description
Members of the fibroblast growth factor (FGF) 19 subfamily, including FGF23, FGF15/19, and FGF21, have a role as endocrine factors which influence the metabolism of inorganic phosphate (Pi) and vitamin D, bile acid, and energy. It has been reported that dietary Pi regulates circulating FGF23. In this study, the short-term effects of dietary Pi restriction on the expression of FGF19 subfamily members in mice were analyzed. An initial analysis confirmed plasma FGF23 levels positively correlated with the amount of dietary Pi. On the other hand, ileal Fgf15 gene expression, but not hepatic Fgf21 gene expression, was up-regulated by dietary Pi restriction. In addition, we observed the increase of plasma 1,25-dihydroxyvitamin D [1,25(OH)2D] levels by dietary Pi restriction, and the up-regulation of ileal Fgf15 mRNA expression by 1,25(OH)2D3 and vitamin D receptor (VDR). Importantly, dietary Pi restriction-induced Fgf15 gene expression was prevented in VDR-knockout mice. Furthermore, diurnal variations of plasma triglyceride concentrations and hepatic mRNA expression of the bile acid synthesis enzyme Cyp7a1 as one of Fgf15 negative target genes was influenced by dietary Pi restriction. These results suggest that dietary Pi restriction up-regulates ileal Fgf15 gene expression through 1,25(OH)2D3 and VDR, and may affect hepatic bile acid homeostasis.
Journal Title
Journal of Clinical Biochemistry and Nutrition
ISSN
18805086
09120009
NCID
AA10710201
Publisher
SOCIETY FOR FREE RADICAL RESEARCH JAPAN
Volume
54
Issue
2
Start Page
102
End Page
108
Published Date
2014-03-01
Remark
内容要旨・審査要旨・論文本文の公開:
内容要旨・審査要旨 : LID201405161005.pdf
論文本文 : k2678_fulltext.pdf
本論文は, 著者Otoki Nakahashiの学位論文として提出され, 学位審査・授与の対象となっている。
著者の申請により要約(2014-07-24公開)に替えて論文全文を公開(2020-04-10)
Rights
© 2014 Society for Free Radical Research Japan
EDB ID
DOI (Published Version)
URL ( Publisher's Version )
FullText File
language
eng
TextVersion
ETD
MEXT report number
甲第2678号
Diploma Number
甲栄第212号
Granted Date
2014-03-24
Degree Name
Doctor of Nutritional Science
Grantor
Tokushima University
departments
Medical Sciences