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ID 114557
Title Alternative
全身麻酔下の患者の血漿サブスタンスP濃度 : 術後嘔気・嘔吐の有用な指標となる
Author
池﨑, 尚子 Tokushima Univeristy
Horikawa, Yousuke T. Tokushima Univeristy|Sharp Rees-Stealy Medical Group
Keywords
General anesthesia
Plasma substance P
PONV
Substance P
Content Type
Thesis or Dissertation
Description
Background: This study investigated plasma concentrations of substance P (SP) in patients undergoing general anesthesia (GA) and postoperative nausea and vomiting (PONV). This prospective, observational, cohort study included 23 patients who underwent scheduled surgery under general anesthesia. Blood was collected from the radial artery at predetermined time points (15–30 mins prior anesthesia, 15–30 mins after surgery/GA, and 24 h after surgery). PONV, SP concentrations, risk factors, and analgesics used were measured.
Findings: Nine of 23 patients experienced PONV. In patients without PONV, SP concentrations significantly decreased (P < 0.0001) at the end of surgery/GA, compared to baseline, and recovered at 24 h after surgery/GA (452.9 ± 146.2 vs. 666.9 ± 176.5 vs. 580.7 ± 168.6 pg/mL, respectively), whereas SP levels were unchanged during surgery/GA and increased at 24 hours after surgery (P = 0.020) in patients with PONV (726.1 ± 167.8 vs. 655.8 ± 168.0 vs. 779.7 ± 220.7 pg/mL, respectively).
Conclusions: These finding suggest that SP levels may be utilized as an objective marker for PONV.
Journal Title
JA Clinical Reports
ISSN
23639024
Publisher
Japanese Society of Anesthesiologists|Springer Nature
Volume
2
Start Page
9
Published Date
2016-06-02
Remark
内容要旨・審査要旨・論文本文の公開
本論文は,著者Takako Kadotaの学位論文として提出され,学位審査・授与の対象となっている。
Rights
© 2016 Kadota et al. Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
EDB ID
DOI (Published Version)
URL ( Publisher's Version )
FullText File
language
eng
TextVersion
ETD
MEXT report number
甲第3425号
Diploma Number
甲医第1456号
Granted Date
2020-04-23
Degree Name
Doctor of Medical Science
Grantor
Tokushima University
departments
Medical Sciences
University Hospital