ID 111414
Title Alternative
発酵大豆食品の摂取と炎症マーカーの関連 : 日本人労働者における横断研究
Fermented soy food and inflammatory makers
Author
Yang, Xiaolin Tokushima University
Aki, Nanako Tokushima University
Bando, Yukiko Tokushima University
Keywords
Soy
Fermented soy food
Inflammation
Interleukin-6
Content Type
Thesis or Dissertation
Description
Epidemiological investigations have shown that consumption of soybeans or soy foods reduces the risk of the development of cardiovascular disease, cancer and osteoporosis. The aim of this study was to determine the associations between different soy foods and inflammatory markers, including high-sensitivity C-reactive protein (hs-CRP), interleukin (IL)-6, and IL-18, in Japanese workers. The cross-sectional study included 1,426 Japanese workers (1,053 men and 373 women) aged 20 to 64 years. Intake of 12 soy foods was estimated by a validated food frequency questionnaire. Associations of total soy foods, fermented soy food, non-fermented soy food, soy isoflavone with hs-CRP, IL-6, and IL-18 levels were examined by general linear model regression analysis. We found that total fermented soy food intake was inversely associated with multivariable-adjusted geometric concentration of IL-6 in men (Q1 : 1.03 pg/mL, Q5 : 0.94 pg/mL ; P for trend = 0.031). Furthermore, it was shown that IL-6 concentrations were inversely associated with miso intake (β= -0.068 ; p = 0.034) and soy sauce intake in men (β= -0.074 ; p = 0.018). This study suggests that intake of total fermented soy food, miso and soy sauce be associated with IL-6 concentrations in Japanese men.
Journal Title
The Journal of Medical Investigation
ISSN
13496867
13431420
NCID
AA11166929
AA12022913
Publisher
Faculty of Medicine Tokushima University
Volume
65
Issue
1-2
Start Page
74
End Page
80
Sort Key
74
Published Date
2018-02
Remark
内容要旨・審査要旨・論文本文の公開
本論文は,著者Xiaolin Yangの学位論文として提出され,学位審査・授与の対象となっている。
著者表記誤記あり(誤)Takako Minamigawa→(正)Takako Minagawa
EDB ID
DOI (Published Version)
URL ( Publisher's Version )
FullText File
language
eng
TextVersion
ETD
MEXT report number
甲第3144号
Diploma Number
甲栄第253号
Granted Date
2018-03-23
Degree Name
Doctor of Nutritional Science
Grantor
Tokushima University
departments
Medical Sciences
University Hospital