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ID 115646
Title Alternative
日本の伝統的な漢方薬である大建中湯は推進性の運動パターンを誘導することにより結腸輸送を促進する
Author
Kubota, Kunitsugu Tsumura & Co.|Tokushima University
Mase, Akihito Tsumura & Co.
Matsushima, Hiroaki Tsumura & Co.
Fujitsuka, Naoki Tsumura & Co.
Yamamoto, Masahiro Tsumura & Co.
Taketomi, Akinobu Hokkaido University
Kono, Toru Tokushima University|Hokkaido University|Sapporo Higashi Tokushukai Hospital
Keywords
Colon
daikenchuto
hydroxy‐α‐sanshool
peristaltic contraction
postoperative ileus
Content Type
Thesis or Dissertation
Description
Background: The traditional Japanese herbal medicine, daikenchuto (DKT), has been used to treat constipation and postoperative ileus. However, the precise mechanisms involved in the pharmacological effects of DKT remain uncertain. The aim of this study was to clarify the effect of DKT on motor patterns and transit activity in the isolated rat colon.
Methods: The entire colon or segments of the proximal colon in rats were isolated and placed in Krebs solution. The motility of the colon was evaluated by analyzing spatiotemporal maps of diameter derived from video imaging and measuring the intraluminal pressure in the anal end of the proximal colon, and the transit time of a plastic bead through the entire isolated colon.
Key Results: Several types of propagating contractions were observed in the isolated entire colon. When DKT was added to Krebs solution, the frequency of large‐extent anal propagating contractions increased. DKT treatment increased the intraluminal pressure in the isolated proximal colon, which was related to the propagating contractions. This effect was abolished by treatment with the neural blocker tetrodotoxin. These findings suggest DKT induced peristaltic contractions in the isolated colon. DKT accelerated colonic transit activity, which was related to peristaltic contractions induction in the colon. These effects were also observed in the colons treated with bethanechol and the active ingredient of DKT, hydroxy‐α‐sanshool.
Conclusions and Inferences: Daikenchuto could enhance colonic transit activity by inducing peristaltic contractions, which may be mediated by the activation of the enteric nervous system in the colon.
Journal Title
Neurogastroenterology & Motility
ISSN
13652982
NCID
AA11017929
Publisher
John Wiley & Sons
Volume
31
Issue
11
Start Page
e13689
Published Date
2019-08-02
Remark
内容要旨・審査要旨・論文本文の公開
本論文は,著者Kunitsugu Kubotaの学位論文として提出され,学位審査・授与の対象となっている。
Rights
This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial License(https://creativecommons.org/licenses/by-nc/4.0/), which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
EDB ID
DOI (Published Version)
URL ( Publisher's Version )
FullText File
language
eng
TextVersion
ETD
MEXT report number
甲第3504号
Diploma Number
甲医第1493号
Granted Date
2021-03-23
Degree Name
Doctor of Medical Science
Grantor
Tokushima University
departments
Medical Sciences