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ID 115811
Author
Iwahashi, Shuichi The University of Tokushima KAKEN Search Researchers
Utsunomiya, Tohru The University of Tokushima KAKEN Search Researchers
Hanaoka, Jun The University of Tokushima
Keywords
Cholangiolocellular carcinoma
Hepatic stem cells
Combined hepatocellular cholangiocarcinoma
Cancer stem cell marker
Content Type
Journal Article
Description
Purpose
Cholangiolocellular carcinoma (CLC) is an extremely rare malignant liver tumor. It is thought to originate from the ductules and/or canals of Hering, where hepatic stem cells (HpSC) are located, but there are few reports on cancer stem cell markers in CLC. Thus, we evaluated the significance of cancer stem cell markers, including CD133, CD44, and EpCAM, in CLC.
Methods
The subjects of this study were three patients with CLC and one patient with an intermediate type of combined hepatocellular cholangiocarcinoma (CHC). The cancer cell markers, CK7, CK19, and EMA, were evaluated immunohistochemically.
Results
Histological examination of the CLC revealed morphologically cholangiolar features and immunohistochemical examination revealed positivity for CD133, CD44, and EpCAM. On the other hand, in the intermediate type of CHC, only CD44 was positive, whereas CD133 and EpCAM were negative.
Conclusion
CLC may have stronger features derived from HpSCs than an intermediate type of CHC.
Journal Title
Surgery Today
ISSN
09411291
14362813
NCID
AA10824685
Publisher
Japan Surgical Society|Springer
Volume
43
Issue
6
Start Page
654
End Page
660
Published Date
2012-11-29
Rights
This article is distributed under the terms of the Creative Commons Attribution License(https://creativecommons.org/licenses/by/4.0/) which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited.
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DOI (Published Version)
URL ( Publisher's Version )
FullText File
language
eng
TextVersion
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departments
University Hospital
Medical Sciences