ID 111374
Author
Bando, Hiroshi Tokushima University|Japan Low Carbohydrate Diet Promotion Association KAKEN Search Researchers
Ebe, Koji Japan Low Carbohydrate Diet Promotion Association|Takao Hospital
Manabe, Takako Kagawa Yoga Association
Bando, Masahiro Tokushima University
Yonei, Yoshikazu Doshisha University
Keywords
Low carbohydrate diet
Super low carbohydrate diet
3-Hydroxybutyric acid
Acetoacetic acid
Ketone bodies
Hyperketonemia
Content Type
Journal Article
Description
Background: Discussion has continued for Calorie Restriction (CR) and low carbohydrate diet (LCD). We have investigated clinical research of LCD in various states for years.
Case and results: The patient was 61 year-old female with HbA1c 10.5%, BMI 21.2 kg/m2 and normal vitals and physicals. Laboratory data were Hb 15.2 g/dl, Alb 5.0 g/dL, Triglyceride 43 mg/dL, HDL-C 89 mg/dL, LDL-C 152 mg/dL, immunoreactivity insulin (IRI) 2.9 μU/mL serum C-peptide reactivity (s-CPR) 1.0 ng/mL, total ketone bodies (T-KB) 3081 μmol/L (28-120), acetoacetic acid (AcAc) 300 μmol/L (14-68), 3-hydroxybutyric acid (3-OHBA) 2781 μmol/L (0-74) Autoantibodies were negative for Glutamate decarboxylase (GADA) or Islet cell (IA-2). She was diagnosed as type 2 diabetes mellitus (T2DM) and started super LCD formula meal with 12% of carbohydrate, and recorded carbohydrate amount about 20-40g per day. HbA1c value was 8.1% and 6.6% in 2 and 4 months, respectively. Significant relationship was shown between carbohydrate intake and hyperketonemia. AcAc/T-KB ratio was 15-20% and around 10%, when T-KB is less than 1000 μmol/L and more than 1000 μmol/L, respectively.
Discussion and conclusion: Authors have proposed 3 types of LCD, which are petit, standard and super, with 40%, 26%, 12% of carbohydrate ratio. Continuing super- LCD usually brings elevated ketone bodies, which might have beneficial function for maintaining the health and anti-aging medicine. Currently obtained results would become the fundamental data and suppose future directions and recommendations for research of ketone bodies in low carbohydrate diet.
Journal Title
Endocrinology and Metabolism : Open Access
Publisher
iMedPub
Volume
2
Issue
1
Start Page
9
Published Date
2018-03-26
Rights
© 2018 Bando H, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
URL ( Publisher's Version )
FullText File
language
eng
TextVersion
Publisher
departments
Oral Sciences